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《中国非小细胞肺癌免疫检查点抑制剂临床应用专家共识(2019年版)》

[Chinese Experts Consensus on Immune Checkpoint Inhibitors for Non-small Cell Lung Cancer (2019 version)].

作者信息

Zhou Caicun, Wang Jie, Bu Hong, Wang Baocheng, Han Baohui, Lu You, Wang Zhehai, Zhu Bo, Wang Ziping, Song Qibin, Ren Shengxiang, Lin Dongmei, He Yayi, Hu Xiaohua, Zhao Hongyun, Qin Shukui

机构信息

Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai 200433, China.

Cancer Hospital Chinese Academy of Medical Sciences, Beijing 100021, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2020 Feb 20;23(2):65-76. doi: 10.3779/j.issn.1009-3419.2020.02.01.

Abstract

Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer, most NSCLC patients are at advanced stage at the time of diagnosis. For patients without sensitive driven-oncogene mutations, chemotherapy is still the main treatment at present, the overall prognosis is poor. Improving outcomes and obtaining long-term survival are the most urgent needs of patients with advanced NSCLC. In recent years, immunotherapy has developed rapidly. Immune checkpoint inhibitors (ICIs), especially targeting programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1), have made a breakthrough in the treatment of NSCLC, beneficial to patients' survival and changed the treatment pattern for NSCLC. It shows more and more important role in the treatment of NSCLC. Led by NSCLC expert committee of Chinese society of clinical oncology (CSCO), relevant experts in this field were organized. On the basis of referring to domestic and foreign literature, systematically evaluating the results of Chinese and foreign clinical trials, and combining the experiences of the experts, the experts group reached an agreement to develop this consensus. It will guide domestic counterparts for better application of ICIs to treat NSCLC.

摘要

非小细胞肺癌(NSCLC)是肺癌最常见的病理类型,大多数NSCLC患者在确诊时已处于晚期。对于没有敏感驱动基因突变的患者,化疗目前仍是主要治疗方法,总体预后较差。改善预后并实现长期生存是晚期NSCLC患者最迫切的需求。近年来,免疫疗法发展迅速。免疫检查点抑制剂(ICIs),尤其是针对程序性死亡蛋白1(PD-1)/程序性死亡配体1(PD-L1)的抑制剂,在NSCLC治疗方面取得了突破,有利于患者生存并改变了NSCLC的治疗模式。它在NSCLC治疗中发挥着越来越重要的作用。在中国临床肿瘤学会(CSCO)NSCLC专家委员会的牵头下,组织了该领域的相关专家。在参考国内外文献、系统评估国内外临床试验结果并结合专家经验的基础上,专家组达成共识制定本共识。它将指导国内同行更好地应用ICIs治疗NSCLC。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6872/7049793/208c7b73879b/zgfazz-23-2-65-2.jpg

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