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2016-2017 年美国医院分离株检测普拉佐米星活性：不同折点标准对氨基糖苷类药物敏感性率的影响。

Activity of Plazomicin Tested against Isolates Collected from U.S. Hospitals in 2016-2017: Effect of Different Breakpoint Criteria on Susceptibility Rates among Aminoglycosides.

机构信息

JMI Laboratories, North Liberty, Iowa, USA

JMI Laboratories, North Liberty, Iowa, USA.

出版信息

Antimicrob Agents Chemother. 2020 Apr 21;64(5). doi: 10.1128/AAC.02418-19.

DOI:10.1128/AAC.02418-19
PMID:32094137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7179652/
Abstract

Plazomicin was active against 97.0% of 8,783 isolates collected in the United States (2016 and 2017), and only 6 isolates carried 16S rRNA methyltransferases conferring resistance to virtually all aminoglycosides. Plazomicin (89.2% to 95.9% susceptible) displayed greater activity than amikacin (72.5% to 78.6%), gentamicin (30.4% to 45.9%), and tobramycin (7.8% to 22.4%) against carbapenem-resistant and extensively drug-resistant isolates. The discrepancies among the susceptibility rates for these agents was greater when applying breakpoints generated using the same stringent contemporary methods applied to determine plazomicin breakpoints.

摘要

硫酸普拉唑米对 2016 年和 2017 年在美国收集的 8783 株分离株中的 97.0%具有活性，只有 6 株分离株携带 16S rRNA 甲基转移酶，对几乎所有氨基糖苷类药物均具有耐药性。硫酸普拉唑米（敏感率为 89.2%至 95.9%）对碳青霉烯类耐药和广泛耐药分离株的活性大于阿米卡星（敏感率为 72.5%至 78.6%）、庆大霉素（敏感率为 30.4%至 45.9%）和妥布霉素（敏感率为 7.8%至 22.4%）。当应用相同的严格当代方法生成的折点来确定硫酸普拉唑米的折点时，这些药物的敏感性率之间的差异更大。

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本文引用的文献

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Plazomicin: A Novel Aminoglycoside for the Treatment of Resistant Gram-Negative Bacterial Infections.泊沙康唑：一种新型氨基糖苷类药物，用于治疗耐药革兰氏阴性菌感染。
Drugs. 2019 Feb;79(3):243-269. doi: 10.1007/s40265-019-1054-3.
2
In vitro activity of Plazomicin against Enterobacteriaceae isolates carrying genes encoding aminoglycoside-modifying enzymes most common in US Census divisions.普拉佐米星对携带美国人口普查分区中最常见的编码氨基糖苷类修饰酶基因的肠杆菌科分离株的体外活性。
Diagn Microbiol Infect Dis. 2019 May;94(1):73-77. doi: 10.1016/j.diagmicrobio.2018.10.023. Epub 2018 Dec 5.
3
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Antimicrob Agents Chemother. 2018 Dec 21;63(1). doi: 10.1128/AAC.02068-18. Print 2019 Jan.
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