Zhao Xue-Min, Zhuang Ping, Li Yong-Jie, Zhang Yu-Qing, Li Jian-Yu, Wang Yun-Peng, Li Ji-Ping
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China.
Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, People's Republic of China.
Neuropsychiatr Dis Treat. 2020 Jan 28;16:313-323. doi: 10.2147/NDT.S229513. eCollection 2020.
The aim of this study was to compare the neuronal firing rate and oscillatory activity of the subthalamic nucleus (STN) between the more affected (MA) and the less affected (LA) hemispheres in Parkinson's disease (PD).
We recorded and analyzed the intra-operative microelectrode recordings (MER) from the STN of 24 PD subjects. Lateralized Unified Parkinson's Disease Rating Scale (UPDRS) III sub-scores (item 20-26) were calculated. The STN corresponding to the MA side was designated as the MA STN while the other side as the LA STN. Single unit characteristics including interspike intervals were identified and spectral analyses were assessed. Further, the mean spontaneous firing rate (MSFR) of neurons was calculated. The correlations between clinical symptoms and neuronal activity were analyzed.
The firing rate in the MA and LA sides were 43.18 ± 0.74 Hz and 36.94 ± 1.32 Hz, respectively, with an increase of 16.9% in the MA group. The number of neurons that oscillated in the Tremor-Frequency Band (TFB), β-Frequency Band (βFB), and the non-oscillatory cells in the MA group were 43, 115, and 62 versus 78, 68, and 54 in the LA group, respectively. The proportions of the three types of neurons were different between both groups. The firing rate of the STN neurons and the UPDRS III sub-scores were positively correlated. Additionally, we observed a positive correlation between the percentage of βFB oscillatory neurons and bradykinesia score.
The firing rate of the STN in the MA hemisphere is higher than in the LA side, following disease progression and there seems to be an increase in firing rate. The βFB oscillatory neurons are at a larger proportion in the MA group while there were larger percentage of TFB oscillatory cells in the LA group. The proportion of βFB oscillatory neurons is selectively correlated with the severity of bradykinesia.
本研究旨在比较帕金森病（PD）中受影响较重（MA）和受影响较轻（LA）半球的丘脑底核（STN）的神经元放电率和振荡活动。
我们记录并分析了24例PD患者STN的术中微电极记录（MER）。计算了单侧统一帕金森病评定量表（UPDRS）III子评分（项目20 - 26）。对应MA侧的STN被指定为MA STN，另一侧为LA STN。识别了包括峰间间隔在内的单个单元特征并评估了频谱分析。此外，计算了神经元的平均自发放电率（MSFR）。分析了临床症状与神经元活动之间的相关性。
MA侧和LA侧的放电率分别为43.18±0.74Hz和36.94±1.32Hz，MA组增加了16.9%。MA组在震颤频率带（TFB）、β频率带（βFB）振荡的神经元数量以及非振荡细胞数量分别为43、115和62，而LA组分别为78、68和54。两组中这三种类型神经元的比例不同。STN神经元的放电率与UPDRS III子评分呈正相关。此外，我们观察到βFB振荡神经元的百分比与运动迟缓评分之间存在正相关。
随着疾病进展，MA半球STN的放电率高于LA侧，且放电率似乎有所增加。MA组中βFB振荡神经元的比例更大，而LA组中TFB振荡细胞的百分比更大。βFB振荡神经元的比例与运动迟缓的严重程度选择性相关。
