Zakaria Zaitun, Idris Zamzuri, Abdul Halim Sanihah, Ghani Abdul Rahman Izaini, Abdullah Jafri M
Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia (USM), Kota Bharu, MYS.
Department of Neurosciences, School of Medical Sciences, Hospital Universiti Sains Malaysia (HUSM), Kota Bharu, MYS.
Cureus. 2023 Feb 16;15(2):e35057. doi: 10.7759/cureus.35057. eCollection 2023 Feb.
The motor circuit in Parkinson's disease (PD) involves the basal ganglia, thalamus, motor cortex, and cerebellum. Hence, subthalamic nucleus (STN) or globus pallidus internus deep brain stimulation is commonly used in treating refractory Parkinson's patients. During the procedure, the local field potential (LPF) is commonly made along the trajectory of the STN. Two cases were assessed, where an electroencephalographic recording at the sensorimotor cortices was also performed with and without stimulation at the optimal STN electrode site. The 'on' stimulation state associated with clinical improvement correlated with a marked reduction in the late theta (7.5 Hz), alpha (10.5 Hz) (Mu wave), and beta (20 Hz) wave power. Besides, more synchronized and coherent brainwaves were noted when the stimulation was 'on'.
帕金森病（PD）的运动回路涉及基底神经节、丘脑、运动皮层和小脑。因此，丘脑底核（STN）或苍白球内侧部深部脑刺激常用于治疗难治性帕金森病患者。在手术过程中，通常沿STN轨迹记录局部场电位（LPF）。评估了两例病例，在最佳STN电极部位进行刺激和不进行刺激的情况下，还在感觉运动皮层进行了脑电图记录。与临床改善相关的“开启”刺激状态与晚期θ波（7.5Hz）、α波（10.5Hz）（μ波）和β波（20Hz）功率的显著降低相关。此外，当刺激“开启”时，观察到脑电波更加同步和相干。
