血清铁蛋白水平对成年镰状细胞贫血男性性腺、催乳素、甲状腺激素及促甲状腺激素的影响
The Effect of Serum Ferritin Level on Gonadal, Prolactin, Thyroid Hormones, and Thyroid Stimulating Hormone in Adult Males with Sickle Cell Anemia.
作者信息
Mostafa Gamal G, Zahran Fawkia E, Omer Sawsan A, Ibrahim Ahmed, Elhakeem Heba
机构信息
Department of Clinical Adult Hematology, Faculty of Medicine, Aswan University, Aswan, Egypt; Haematology, Hereditary Blood Disease Centre- Hofuf, Hofuf, Kingdom of Saudi Arabia.
Department of Internal Medicine, Faculty of Medicine for Girls, Al- Azhar University, Cairo, Egypt.
出版信息
J Blood Med. 2020 Jan 28;11:27-32. doi: 10.2147/JBM.S232562. eCollection 2020.
BACKGROUND
Sickle cell anaemia (SCA) is an inherited hemoglobinopathy resulting in sickling of erythrocytes that cause micro-vascular obstruction leading to acute complications and chronic organ damage. Adults with SCA have endocrine complications and metabolic alterations. The aim of this study was to assess the association between gonadal and thyroid hormones with iron indices and to explore the potential association between serum ferritin levels and sex hormones in adult males with sickle cell disease in New Prince Saud Bin Jalawy Hospital (NPSBJH) in Hofuf city (Eastern region of Saudi Arabia) where there are many patients with SCA.
METHODS
A cross-sectional analytical study was carried out in the Haematology Clinic at NPSBJH in 2018. A total of eighty (80) male patients with sickle cell anaemia were included in this study and were divided into two groups according to serum ferritin level. Group I (G-I): Included 40 male patients with high serum ferritin level and group II (G-II): included 40 male patients with normal serum ferritin level.
RESULTS
There was a significant difference in height/cm between GI and Gil, P value= 0.006. Serum ferritin was significantly higher in GI (P value= 0.000), and serum TIBC was significantly higher in G-II. (P value= 0.022). Testosterone level was significantly higher in G-II (P value= 0.018). Luteinizing hormone (LH) was significantly higher in group I (P-value 0.019). There was a significant relation between serum ferritin level in G-I and the following: serum iron, TIBC, serum testosterone, LH, prolactin, free T3 and free T4.
CONCLUSION
Adult males with SCD with high serum ferritin level were shorter than adult males with SCD who had normal serum ferritin level and had a significant lower level of serum testosterone and significant high level of LH and this was most likely due to endocrine dysfunction secondary to high ferritin level and iron overload.
背景
镰状细胞贫血（SCA）是一种遗传性血红蛋白病，可导致红细胞镰变，引起微血管阻塞，进而导致急性并发症和慢性器官损害。成年SCA患者存在内分泌并发症和代谢改变。本研究旨在评估性腺激素和甲状腺激素与铁指标之间的关联，并探讨沙特阿拉伯东部胡富夫市新王子沙特·本·贾拉维医院（NPSBJH）成年男性镰状细胞病患者血清铁蛋白水平与性激素之间的潜在关联，该医院有许多SCA患者。
方法
2018年在NPSBJH血液科进行了一项横断面分析研究。本研究共纳入80例男性镰状细胞贫血患者，并根据血清铁蛋白水平分为两组。第一组（G-I）：包括40例血清铁蛋白水平高的男性患者；第二组（G-II）：包括40例血清铁蛋白水平正常的男性患者。
结果
G-I组和G-II组之间身高/cm存在显著差异，P值 = 0.006。G-I组血清铁蛋白显著更高（P值 = 0.000），G-II组血清总铁结合力（TIBC）显著更高（P值 = 0.022）。G-II组睾酮水平显著更高（P值 = 0.018）。第一组促黄体生成素（LH）显著更高（P值 = 0.019）。G-I组血清铁蛋白水平与以下指标之间存在显著关系：血清铁、TIBC、血清睾酮、LH、催乳素、游离T3和游离T4。
结论
血清铁蛋白水平高的成年男性SCD患者比血清铁蛋白水平正常的成年男性SCD患者更矮，血清睾酮水平显著更低，LH水平显著更高，这很可能是由于高铁蛋白水平和铁过载继发的内分泌功能障碍所致。
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