Arai Toshio, Yamada Hiroki, Edagawa Takeya, Yoshida Satoshi, Maekura Shunji, Nakachi Kenichiro
Department of Gastroenterology, Hashimoto Municipal Hospital, Hashimoto, Japan.
Department of Pathology, Hashimoto Municipal Hospital, Hashimoto, Japan.
Case Rep Gastroenterol. 2020 Jan 20;14(1):34-38. doi: 10.1159/000505510. eCollection 2020 Jan-Apr.
Ganglioneuromas (GNs) in adults are uncommon clinical entities, especially in the colon. Patients with GNs without multiple endocrine neoplasia or neurofibromatosis-I are normally asymptomatic; however, GNs can present with abdominal pain, weight loss, bleeding, and anemia, depending on the size and location. Here, we present a case of solitary colonic GN treated with endoscopic mucosal resection. A 40-year-old Japanese outpatient with a positive fecal occult blood test visited our hospital. We performed diagnostic colonoscopy, which revealed a polyp of 15-mm diameter in the ascending colon. Electromagnetic resonance imaging was performed, and the histological examination revealed benign polypoid spindle-cell proliferation, ganglion cells, and thick nerve bundles, which was positive for S-100 protein immunoreactivity consistent with GN.
成人神经节神经瘤（GNs）是罕见的临床病症，在结肠中尤为少见。没有多发性内分泌腺瘤病或I型神经纤维瘤病的GNs患者通常无症状；然而，根据大小和位置不同，GNs可能表现为腹痛、体重减轻、出血和贫血。在此，我们报告一例采用内镜黏膜切除术治疗的孤立性结肠GNs病例。一名40岁日本门诊患者粪便潜血试验呈阳性，前来我院就诊。我们进行了诊断性结肠镜检查，发现升结肠有一个直径15毫米的息肉。进行了磁共振成像检查，组织学检查显示为良性息肉样梭形细胞增生、神经节细胞和粗大神经束，S-100蛋白免疫反应呈阳性，符合GNs诊断。
