Jafari Elham, Tabrizchi Hamid, Mangeli Foroogh
Pathology and Stem Cell Research Center, kerman University of Medical Science, Kerman, Iran.
Department of Pathology, Kerman University of Medical Sciences, Kerman, Iran.
Iran J Pathol. 2020 Winter;15(1):53-56. doi: 10.30699/IJP.2019.106979.2111.
Carotid body paraganglioma is a neuroendocrine neoplasm of the mandibular region. Due to its prominent stromal alternations, carotid body paraganglioma is a great emulator of other neoplasms in the head and neck region especially in metastatic tumors and its definite diagnosis is a great challenge. To the best of our knowledge, the most frequently reported variant is sclerosing and paraganglioma with a prominent lymphoplasmacytic infiltration is extremely rare. We report a rare case of a carotid body lymphoplasmacytic paraganglioma presented as a single asymptomatic mass of the right mandibular region in a 45-year-old woman. In order to exclude other possibilities, the use of immunohistochemistry is essential which shows a strong positive immunoreaction for chromogranin and synaptophysin. Surgical resection is the treatment of choice which is replaced with radiotherapy in contraindications. Overall, the tumor has a favorable clinical outcome.
颈动脉体副神经节瘤是下颌区域的一种神经内分泌肿瘤。由于其显著的间质改变，颈动脉体副神经节瘤极易与头颈部其他肿瘤混淆，尤其是转移性肿瘤，其明确诊断极具挑战性。据我们所知，最常报道的变异型是硬化型，而伴有显著淋巴浆细胞浸润的副神经节瘤极为罕见。我们报告了一例罕见的颈动脉体淋巴浆细胞性副神经节瘤病例，该病例表现为一名45岁女性右下颌区域的单个无症状肿块。为排除其他可能性，免疫组织化学检查至关重要，其显示嗜铬粒蛋白和突触素呈强阳性免疫反应。手术切除是首选治疗方法，禁忌证时则采用放疗替代。总体而言，该肿瘤具有良好的临床预后。
