Suppr超能文献

改善痛风患者的治疗效果。

Better outcomes for patients with gout.

机构信息

St Vincent's Clinical School, UNSW Medicine, UNSW Sydney, Sydney, Australia.

Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, Australia.

出版信息

Inflammopharmacology. 2020 Oct;28(5):1395-1400. doi: 10.1007/s10787-020-00694-7. Epub 2020 Feb 25.

Abstract

Gout is increasing in prevalence despite effective pharmacotherapies. Barriers to effective management are largely educational deficiencies. Sufferers, usually men, need to understand more about gout, especially that maintaining serum urate below 0.36 mmol/L will eliminate recurrent attacks. Also, of great importance is appreciating that sub-optimal adherence to urate-lowering therapy (ULT) will result in a return of attacks. Prescribers also need to understand that acute attacks are likely to occur in the first few months of urate-lowering therapy (ULT), but these can be mitigated by commencing with a dose of ULT reflective of renal function and escalating the dose slowly, every 2-5 weeks until target serum urate is achieved. Prophylaxis against acute attacks over the initial 6 months period of ULT can be enhanced further with concomitant colchicine or nonsteroidal anti-inflammatory drugs (NSAIDs).Gout is largely managed in primary care. Rates of adherence to ULT are 50% or less, worse than most other chronic illnesses. Efforts at educating primary care physicians to, firstly, manage gout effectively and, secondly, to educate their gout patients sufficiently have not been successful. Allied health practitioners, such as nurses, working with prescribers in primary care settings and given the mandate to educate and manage patients with gout, have been spectacularly effective. However, this approach is resource intensive. 'Personalised' eHealth interventions show promise as an alternative strategy, notably in improving adherence to ULT.Numerous applications for smart phones (apps) are now available to assist people with chronic health conditions. Their design needs to accommodate the barriers and enablers perceived by patients to maintaining adherence to prescribed therapies. Personalised feedback of serum urate may represent an important enabler of adherence to ULT in the case of gout.Harnessing mobile apps to support patients managing their chronic illnesses represents an important opportunity to enhance health outcomes. Rigorous, patient-centred and driven development is critical. These tools also require careful evaluation for effectiveness.

摘要

尽管有有效的药物治疗,但痛风的发病率仍在上升。有效管理的主要障碍是教育方面的不足。痛风患者(通常为男性)需要更深入地了解痛风,特别是要知道将血清尿酸控制在 0.36mmol/L 以下将消除反复发作。此外,了解到降低尿酸治疗(ULT)的依从性不理想会导致发作的复发也是非常重要的。医生也需要了解到,在开始 ULT 的最初几个月中,急性发作很可能会发生,但可以通过起始剂量反映肾功能并缓慢逐渐增加剂量(每 2-5 周增加一次剂量),直至达到目标血清尿酸来缓解。在 ULT 的最初 6 个月期间,预防性使用秋水仙碱或非甾体抗炎药(NSAIDs)可以进一步增强急性发作的预防效果。痛风主要在初级保健中进行管理。ULT 的依从率为 50%或更低,比大多数其他慢性疾病更差。向初级保健医生进行教育,以首先有效管理痛风,其次充分教育他们的痛风患者的努力并未取得成功。在初级保健环境中与医生合作的辅助卫生从业人员,例如护士,在教育和管理痛风患者方面非常有效。但是,这种方法需要大量资源。作为替代策略,“个性化”电子健康干预措施显示出了希望,尤其是在提高 ULT 的依从性方面。现在有许多智能手机应用程序(apps)可用于帮助患有慢性疾病的人。它们的设计需要适应患者认为维持遵医嘱治疗的障碍和促进因素。个性化的血清尿酸反馈可能是提高痛风患者对 ULT 依从性的重要促进因素。利用手机应用程序支持患者管理其慢性疾病是改善健康结果的重要机会。严格,以患者为中心并具有推动力的开发至关重要。这些工具还需要进行仔细的有效性评估。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验