Falk G L, Gray-Weale A C, Meyer H J, Johnson S, Lusby R J
Department of Surgery, Repatriation General Hospital, Concord, Australia.
J Cardiovasc Surg (Torino). 1988 Nov-Dec;29(6):697-700.
Bilateral carotid endarterectomy (CEA) was performed in a series of 16 dogs, one of the arteriotomies being closed by direct suture and the other with an autologous vein patch. Platelets obtained at the induction of the anaesthetic were labelled with Indium 111 Oxine and subsequently re-infused prior to restoration of blood flow. Post-operative sequential platelet counts using a Selo CSZ counter were undertaken, which demonstrated a substantial rise at the sites of CEA. These counts rose to peak levels between 7-88 minutes after declamping with a median peak time of 20 minutes. Continued high levels of labelled platelet accumulation persisted for 48-96 hours following CEA and in some instances persisted for three weeks. These studies suggest that antiplatelet agents should therefore be active when carotid declamping occurs and administered for at least three weeks following CEA.
对16只犬进行了双侧颈动脉内膜切除术（CEA），其中一个动脉切开处采用直接缝合关闭，另一个采用自体静脉补片关闭。在麻醉诱导时采集的血小板用铟111草酸盐标记，随后在恢复血流前重新注入。使用Selo CSZ计数器进行术后连续血小板计数，结果显示CEA部位血小板数量大幅增加。这些计数在松开夹闭后7 - 88分钟达到峰值水平，中位峰值时间为20分钟。CEA后标记血小板的持续高水平积累持续48 - 96小时，在某些情况下持续三周。这些研究表明，因此抗血小板药物应在颈动脉夹闭时发挥作用，并在CEA后至少使用三周。
