铟-111标记血小板对动脉切开闭合的急性反应。

The acute response of indium-111 labelled platelets to arteriotomy closure.

作者信息

Nash P A, Lord R S, Zhang H Q, Yeates P, Whitfeld M J, Freund J, Pocock N A, Yeates M, Goh K H

机构信息

Surgical Professorial Unit, St. Vincent's Hospital, University of New South Wales, Sydney, Australia.

出版信息

J Cardiovasc Surg (Torino). 1988 Nov-Dec;29(6):701-6.

PMID:3209613

Abstract

A standard 40 mm arteriotomy was created in canine iliac and carotid arteries and then closed by either direct suture without a patch, with a vein patch or with a polytetrafluoroethylene patch (PTFE). The uptake of 111-Indium oxine labelled platelets at 2 hours after operation was compared between the groups. Arteriotomies closed with a PTFE patch demonstrated significantly greater platelet aggregation than those closed with a vein patch. Primary closure without a patch was associated with the least platelet uptake of all (PTFE versus vein patch, P less than 0.01; PTFE versus no patch, P less than 0.01; vein patch versus no patch, P less than 0.05). Light and electron microscopy confirmed the radioisotopic findings.

摘要

在犬的髂动脉和颈动脉上做一个标准的40毫米动脉切口，然后分别采用无补片直接缝合、静脉补片或聚四氟乙烯补片（PTFE）进行闭合。比较各组术后2小时111-铟喷曲肽标记血小板的摄取情况。与采用静脉补片闭合的动脉切口相比，采用PTFE补片闭合的动脉切口血小板聚集明显更多。无补片的一期闭合在所有情况中血小板摄取最少（PTFE与静脉补片相比，P<0.01；PTFE与无补片相比，P<0.01；静脉补片与无补片相比，P<0.05）。光镜和电镜检查证实了放射性同位素检查结果。