Rehabilitation Sciences, University of British Columbia, Vancouver, Canada.
British Columbia Children's Hospital Research Institute, Vancouver, Canada.
Genes Brain Behav. 2020 Apr;19(4):e12647. doi: 10.1111/gbb.12647. Epub 2020 Mar 4.
Motor impairments are a common feature of many neurodevelopmental disorders; in fact, over 50% of children with Attentional Deficit Hyperactivity Disorder or Autism Spectrum Disorder may have a co-occurring diagnosis of developmental coordination disorder (DCD). DCD is a neurodevelopmental disorder of unknown etiology that affects motor coordination and learning, significantly impacting a child's ability to carry out everyday activities. Animal models play an important role in scientific investigation of behaviour and the mechanisms and processes that are involved in control of motor actions. The purpose of this paper is to present an approach in the mouse directed to gain behavioral and genetic insights into DCD that is designed with high face validity, construct validity and predictive validity. Pre-clinical and clinical expertise is used to establish a set of scientific criteria that the model will meet in order to investigate the potential underlying causes of DCD.
运动障碍是许多神经发育障碍的共同特征；事实上，超过 50%的注意力缺陷多动障碍或自闭症谱系障碍儿童可能同时患有发育性协调障碍 (DCD)。DCD 是一种病因不明的神经发育障碍，影响运动协调和学习，严重影响儿童进行日常活动的能力。动物模型在行为以及控制运动动作所涉及的机制和过程的科学研究中起着重要作用。本文旨在介绍一种针对小鼠的方法，旨在通过行为和遗传手段深入了解 DCD，该方法具有高表面效度、高结构效度和高预测效度。临床前和临床专业知识用于建立一套科学标准，模型将满足这些标准，以研究 DCD 的潜在根本原因。
