Vascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino IRCCS, Milan, Italy
Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy
Curr Stem Cell Res Ther. 2020;15(8):696-710. doi: 10.2174/1574888X15666200225124451.
Nowadays, cardiac regeneration is an emerging topic in the cardiovascular field because of the compelling need for effective therapies for repairing or replacing cardiac tissue damaged by pathological or physiological conditions. Indeed, irreversible myocardial remodeling which follows acute myocardial infarction represents a serious burden of this century. In this context, a great improvement in pharmacological and interventional techniques is accompanied by a big challenge of cardiac regenerative medicine. In the last 20 years, several clinical trials tried to investigate the role of different types of stem cells in promoting cardiac repair. However, the promising results obtained in the preclinical trials have not yet been reproduced in patients. Thus, the development of novel strategies to improve stem cell efficiency became imperative. Here, an overview of the more recent cell types proposed for cardiac regeneration is presented, together with the most interesting approaches to enhance cell regenerative potential as well as cell-free approaches.
如今，心脏再生是心血管领域的一个新兴课题，因为迫切需要有效的治疗方法来修复或替代因病理或生理条件而受损的心脏组织。事实上，急性心肌梗死后不可逆的心肌重构是本世纪的一个严重负担。在这种情况下，药理学和介入技术的巨大进步伴随着心脏再生医学的巨大挑战。在过去的 20 年里，有几项临床试验试图研究不同类型的干细胞在促进心脏修复中的作用。然而，在临床前试验中获得的有希望的结果尚未在患者中得到重现。因此，开发提高干细胞效率的新策略变得势在必行。在这里，我们对最近提出的用于心脏再生的细胞类型进行了综述，同时还介绍了增强细胞再生潜能的最有趣的方法以及无细胞方法。
