Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN.
Eye Contact Lens. 2020 Mar;46 Suppl 2(Suppl 2):S109-S121. doi: 10.1097/ICL.0000000000000688.
Allergic conjunctival diseases (ACDs) are a group of ocular allergies that include allergic conjunctivitis, atopic keratoconjunctivitis, vernal keratoconjunctivitis, and giant papillary conjunctivitis. Although a large body of information exists on the pathophysiology of ACDs, this has not yet lead to the development of clear recommendations and guidelines for the diagnosis of ACDs or development of conclusive and objective diagnostic tools. Identification of objectively measurable biomarkers that represent the molecular and cellular mechanisms associated with ACDs will be an important step toward achieving these aims. This is a comprehensive review of biological markers that have the potential to become "biomarker(s)" for ACDs and aid in the classification, diagnosis, and development of new therapeutic strategies for these group of allergic conditions.
变应性结膜炎（ACDs）是一组眼部过敏疾病，包括过敏性结膜炎、特应性角结膜炎、春季角结膜炎和巨大乳头性结膜炎。尽管有关 ACDs 的病理生理学已经有大量的信息，但这并没有导致对 ACDs 的诊断的明确建议和指南的制定，也没有开发出明确和客观的诊断工具。确定与 ACDs 相关的分子和细胞机制的客观可测量的生物标志物将是实现这些目标的重要步骤。这是一篇关于生物标志物的全面综述，这些生物标志物有可能成为 ACD 的“生物标志物”，并有助于这些过敏性疾病的分类、诊断和新治疗策略的开发。
