Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing.
Eye Center, the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China.
J Glaucoma. 2020 Jun;29(6):467-472. doi: 10.1097/IJG.0000000000001472.
After a short-term intraocular pressure (IOP) elevation, the central retinal vein caliber may be widened at lower IOP rise levels, while be compressed at higher IOP rise values.
The purpose of this study was to investigate changes in the calibers of the central retinal vein trunk (CRVT) and central retinal artery trunk (CRAT) trunk during a short-term elevation of IOP.
A prospective observational study. Acute primary angle-closure suspects underwent a dark room prone provocative test (DRPPT) for 2 hours. Before and at the end of the test, tonometry, swept-source optical coherence tomography, and nonmydriatic fundus photography were performed. The calibers of the CRVT and CRAT were measured on the fundus photos taken at baseline and at the end of the DRPPT.
The study included 101 eyes (61 individuals; mean age: 54.8±9.3 y; range: 30 to 70 y) which showed an increase in IOP by 9.6±9.0 mm Hg (range: 2.3 to 46.7 mm Hg). From baseline to the end of the DRPPT, the mean CRVT caliber increased from 101.8±25.9 to 107.7±26.6 μm (P<0.001), while the CRAT caliber did not differ significantly (110.3±24.2 vs. 109.7±21.5 μm; P=0.54) during the test. The CRVT widening was larger in the subgroup with IOP rise of <6 mm Hg than in the subgroup with an IOP rise of 6 to 15 mm Hg, while in the subgroup with an IOP rise of >15 mm Hg the CRVT caliber did not change significantly (P=0.20) during the test.
A physiological short-term IOP rise at lower levels of IOP elevation led to a widening of the CRVT, while at higher IOP values, the further IOP-rise may have compressed the retinal vein. Because of higher intraluminal pressure values, the retinal artery diameters were not affected by the IOP-rise.
在短期眼压升高后，中央视网膜静脉的口径可能在较低的眼压升高水平下变宽，而在较高的眼压升高值下被压缩。
本研究旨在探讨短期眼压升高过程中中央视网膜静脉主干（CRVT）和中央视网膜动脉主干（CRAT）的变化。
前瞻性观察研究。急性原发性闭角型青光眼疑似患者进行暗室俯卧位激发试验（DRPPT）2 小时。在试验前后，进行眼压测量、扫频源光学相干断层扫描和非散瞳眼底照相。在 DRPPT 前后的眼底照片上测量 CRVT 和 CRAT 的口径。
本研究纳入 101 只眼（61 人；平均年龄：54.8±9.3 岁；范围：30 至 70 岁），眼压升高 9.6±9.0mmHg（范围：2.3 至 46.7mmHg）。从基线到 DRPPT 结束时，CRVT 平均口径从 101.8±25.9μm 增加到 107.7±26.6μm（P<0.001），而 CRAT 口径在试验过程中没有显著差异（110.3±24.2μm 比 109.7±21.5μm；P=0.54）。在眼压升高<6mmHg 的亚组中，CRVT 变宽大于眼压升高 6-15mmHg 的亚组，而在眼压升高>15mmHg 的亚组中，CRVT 口径在试验过程中没有显著变化（P=0.20）。
在较低的眼压升高水平下，生理上的短期眼压升高导致 CRVT 变宽，而在较高的眼压值下，进一步的眼压升高可能会压迫视网膜静脉。由于管腔内压力值较高，视网膜动脉直径不受眼压升高的影响。
