Berezin I, Huizinga J D, Daniel E E
Department of Neurosciences, McMaster University, Hamilton, Ontario, Canada.
J Comp Neurol. 1988 Jul 1;273(1):42-51. doi: 10.1002/cne.902730105.
The ultrastructure of the region shown to be essential for pacemaking activity of the circular muscle of the canine colon was studied. This region, at the inner border of the circular muscle, consists of a network of several layers of interstitial cells of Cajal type III. These are interconnected to one another and to the adjacent circular muscle cells by numerous gap junctions. Elsewhere in circular muscle, gap junctions are rare and small. In addition, interstitial cells are in close (often less than 20 nm) contact with nerve varicosities containing large granular vesicles or sometimes small granular vesicles. The morphology of interstitial cells resembles that of others of type III. It is suggested that this arrangement of interstitial cells, circular smooth muscles, and nerves allows for a tightly coupled network of membrane oscillators to be subject to neural modulation.
对犬结肠环形肌起搏活动至关重要的区域的超微结构进行了研究。该区域位于环形肌的内边界，由几层 Cajal Ⅲ型间质细胞组成的网络构成。这些细胞通过大量缝隙连接相互连接，并与相邻的环形肌细胞相连。在环形肌的其他部位，缝隙连接很少且很小。此外，间质细胞与含有大颗粒囊泡或有时小颗粒囊泡的神经膨体紧密接触（通常小于20纳米）。间质细胞的形态与其他Ⅲ型细胞相似。有人认为，间质细胞、环形平滑肌和神经的这种排列方式使得膜振荡器的紧密耦合网络能够接受神经调节。
