Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Medical Physics Department, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Steroids. 2020 Jun;158:108615. doi: 10.1016/j.steroids.2020.108615. Epub 2020 Feb 22.
There are conflicting results regarding the exact effect of the vitamin D receptor (VDR) gene polymorphisms on the susceptibility to multiple sclerosis (MS). Therefore, we aimed to investigate the impact of four major studied VDR gene polymorphisms consisting of ApaI, BsmI, FokI, and TaqI on the risk of MS in the Iranian population. A literature search was performed in various databases to find case-control studies evaluating the association between VDR gene polymorphisms and MS risk in Iran. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated. Subgroup analyze was performed to detect potential sources of heterogeneity. A total of 1206 cases and 1402 controls in nine case-control studies were included. ApaI was the only variant which showed statistically significant relation in allelic (OR = 0.54 (95% CI: 0.37-0.79); P = 0.00), homozygote (OR = 3.48 (95% CI: 1.7-6.9); P = 0.00), dominant (OR = 0.56 (95% CI: 0.3-0.79); P = 0.01), and recessive (OR = 0.35 (95% CI: 0.18-0.66); P = 0.00) models. The TaqI polymorphism showed a significant negative association with MS only in the homozygote model (OR = 0.28 (95% CI: 0.08-0.9); P = 0.04). The BsmI polymorphism also showed significant relation in allelic (OR = 0.69 (95% CI: 0.51-0.94); P = 0.01), homozygote (OR = 0.46 (95% CI: 0.25-0.86); P = 0.01), and recessive OR = 0.56 (95% CI: 0.39-0.8); P = 0.00) models after performing sensitivity analysis. FokI polymorphism showed no significant association with MS risk. ApaI and TaqI TT genotype were found contributing to MS susceptibility and BsmI and FokI showed no relation with MS susceptibility in the Iranian population.
关于维生素 D 受体 (VDR) 基因多态性对多发性硬化症 (MS) 易感性的确切影响，结果相互矛盾。因此，我们旨在研究构成 ApaI、BsmI、FokI 和 TaqI 的四个主要研究 VDR 基因多态性对伊朗人群中 MS 风险的影响。在各种数据库中进行了文献检索，以寻找评估 VDR 基因多态性与伊朗 MS 风险之间关联的病例对照研究。提取数据并计算比值比 (OR) 和 95%置信区间 (CI)。进行亚组分析以检测潜在的异质性来源。共有 9 项病例对照研究纳入了 1206 例病例和 1402 例对照。ApaI 是唯一在等位基因 (OR=0.54 (95%CI: 0.37-0.79); P=0.00)、纯合子 (OR=3.48 (95%CI: 1.7-6.9); P=0.00)、显性 (OR=0.56 (95%CI: 0.3-0.79); P=0.01) 和隐性 (OR=0.35 (95%CI: 0.18-0.66); P=0.00) 模型中具有统计学意义的关联的变体。TaqI 多态性仅在纯合子模型中与 MS 呈显著负相关 (OR=0.28 (95%CI: 0.08-0.9); P=0.04)。BsmI 多态性在等位基因 (OR=0.69 (95%CI: 0.51-0.94); P=0.01)、纯合子 (OR=0.46 (95%CI: 0.25-0.86); P=0.01) 和隐性 (OR=0.56 (95%CI: 0.39-0.8); P=0.00) 模型中也表现出显著的相关性。进行敏感性分析后，FokI 多态性与 MS 风险无显著关联。在伊朗人群中，ApaI 和 TaqI TT 基因型被发现有助于 MS 易感性，而 BsmI 和 FokI 与 MS 易感性无关。
