Department of Endocrinology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Arch Med Res. 2019 Aug;50(6):350-361. doi: 10.1016/j.arcmed.2019.10.007. Epub 2019 Oct 31.
Previous studies have reported vitamin D receptor (VDR) polymorphisms in multiple sclerosis (MS); however, the results remain contradictory. This study aimed to investigate the association between VDR polymorphisms and the risk of MS.
PubMed and Embase databases were searched to obtain eligible studies. Data were calculated by odds ratios (OR) with 95% confidence intervals (CI).
Twenty seven case-control studies with 4879 MS patients and 5402 controls were included. There was no significant association between ApaI polymorphisms and MS in the overall population. In Asians, no association was found between ApaI polymorphism and MS in the recessive, dominant, Codominant (OR1), Codominant (OR2), Codominant (OR3) models and allele contrast. Similar results were obtained between BsmI polymorphisms and MS. The association between TaqI polymorphism and MS showed significance in the recessive, homozygous, codominant (OR3) models in the overall population and Caucasians. The dominant model showed no association of Taq I polymorphism with MS risk in HLA-DRB115-positive and HLA-DRB115-negative groups. FokI polymorphism with MS was found in Codominant (OR3) model in the overall population. In Asians, FokI polymorphism showed association with MS in recessive, dominant, Codominant (OR1), Codominant (OR3) models and allele contrast. Subgroup analysis of sex showed no associations between TaqI or FokI polymorphism and MS risk in males or females in all models or allele contrast.
The VDR TaqI polymorphisms showed association with MS risk, especially in Caucasians. In Asians, ApaI and FokI polymorphisms correlated with MS risk, while BsmI polymorphisms showed no association with MS.
先前的研究报告了多发性硬化症（MS）中维生素 D 受体（VDR）的多态性；然而，结果仍然存在矛盾。本研究旨在探讨 VDR 多态性与 MS 风险之间的关联。
检索 PubMed 和 Embase 数据库以获取合格的研究。使用比值比（OR）及其 95%置信区间（CI）计算数据。
共纳入 27 项病例对照研究，包括 4879 例 MS 患者和 5402 例对照。总体人群中 ApaI 多态性与 MS 之间无显著相关性。在亚洲人群中，ApaI 多态性与 MS 之间在隐性、显性、共显性（OR1）、共显性（OR2）、共显性（OR3）模型和等位基因对比中无关联。BsmI 多态性与 MS 之间也存在相似的结果。TaqI 多态性与 MS 的关联在总体人群和白种人中在隐性、纯合子、共显性（OR3）模型中具有统计学意义。在 HLA-DRB115 阳性和 HLA-DRB115 阴性组中，显性模型显示 Taq I 多态性与 MS 风险无关。FokI 多态性与 MS 有关，在总体人群中在共显性（OR3）模型中。在亚洲人群中，FokI 多态性与 MS 之间在隐性、显性、共显性（OR1）、共显性（OR3）模型和等位基因对比中存在关联。性别亚组分析显示，在所有模型或等位基因对比中，TaqI 或 FokI 多态性与男性或女性的 MS 风险均无关。
VDR TaqI 多态性与 MS 风险相关，尤其是在白种人中。在亚洲人群中，ApaI 和 FokI 多态性与 MS 风险相关，而 BsmI 多态性与 MS 无关。
