Institute for Datability Science, Osaka University, Suita, Japan.
Institute for Datability Science, Osaka University, Suita, Japan.
Biophys J. 2020 Mar 24;118(6):1466-1478. doi: 10.1016/j.bpj.2020.01.037. Epub 2020 Feb 5.
Cancer cells collectively form a large-scale structure for their growth. In this article, we report that HeLa cells, epithelial-like human cervical cancer cells, aggressively migrate on Matrigel and form a large-scale structure in a cell-density-dependent manner. To explain the experimental results, we develop a simple model in which cells interact and migrate using the two fundamentally different types of force, remote and contact forces, and show how cells form a large-scale structure. We demonstrate that the simple model reproduces experimental observations, suggesting that the remote and contact forces considered in this work play a major role in large-scale structure formation of HeLa cells. This article provides important evidence that cancer cells form a large-scale structure and develops an understanding into the poorly understood mechanisms of their structure formation.
癌细胞集体形成了一个大规模的生长结构。在本文中，我们报告了人宫颈癌细胞上皮样的 HeLa 细胞在 Matrigel 上积极迁移，并以细胞密度依赖性的方式形成大规模结构。为了解释实验结果，我们开发了一个简单的模型，其中细胞使用远程和接触两种基本不同类型的力相互作用和迁移，并展示了细胞如何形成大规模结构。我们证明，该简单模型再现了实验观察结果，表明本文中考虑的远程和接触力在 HeLa 细胞的大规模结构形成中起着重要作用。本文提供了重要证据，表明癌细胞形成了一个大规模结构，并深入了解了其结构形成的机制。
