Department of Neurology, Franz Tappeiner Hospital, Merano, Italy; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center, Salzburg, Austria; Karl Landsteiner Institut für Neurorehabilitation und Raumfahrtneurologie, Salzburg, Austria.
Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Karl Landsteiner Institut für Neurorehabilitation und Raumfahrtneurologie, Salzburg, Austria.
Neurosci Lett. 2020 Mar 23;722:134860. doi: 10.1016/j.neulet.2020.134860. Epub 2020 Feb 22.
In patients with amyotrophic lateral sclerosis (ALS) a motor cortical hyperexcitability has been reported in transcranial magnetic stimulation studies, but little is known about the neuronal excitability in other cortical areas. The aim of the present study was the functional evaluation of the sensory cortex in subjects with ALS by assessing the high-frequency somatosensory evoked potentials (HF-SEP). No significant HF-SEP abnormalities were observed in ALS patients with disease duration of <2 years, while the patients with a disease duration of>2 years we found a large amplitude reduction of post-synaptic HF-SEP burst. Since post-synaptic burst of HF-SEP is thought to reflect the activity of cortical inhibitory interneurons, our findings provide further evidence that disinhibition is a primary characteristic of ALS that also involves the somatosensory cortex.
在肌萎缩侧索硬化症（ALS）患者的经颅磁刺激研究中报道了运动皮质兴奋性过高，但对于其他皮质区域的神经元兴奋性知之甚少。本研究的目的是通过评估高频体感诱发电位（HF-SEP）来对 ALS 患者的感觉皮质进行功能评估。在病程<2 年的 ALS 患者中，未观察到高频体感诱发电位异常，而病程>2 年的患者发现突触后高频体感诱发电位爆发的振幅明显降低。由于高频体感诱发电位的突触后爆发被认为反映了皮质抑制性中间神经元的活动，我们的发现进一步证明了去抑制是 ALS 的一个主要特征，它还涉及体感皮质。
