Neuromuscular Unit, Department of Neurology, Hospital del Mar, 08003 Barcelona, Spain.
Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences and CIBERNED, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Int J Mol Sci. 2022 Dec 8;23(24):15521. doi: 10.3390/ijms232415521.
Although amyotrophic lateral sclerosis (ALS) is pre-eminently a motor disease, the existence of non-motor manifestations, including sensory involvement, has been described in the last few years. Although from a clinical perspective, sensory symptoms are overshadowed by their motor manifestations, this does not mean that their pathological significance is not relevant. In this review, we have made an extensive description of the involvement of sensory and autonomic systems described to date in ALS, from clinical, neurophysiological, neuroimaging, neuropathological, functional, and molecular perspectives.
虽然肌萎缩侧索硬化症（ALS）主要是一种运动疾病，但近年来已经描述了包括感觉受累在内的非运动表现。虽然从临床角度来看，感觉症状被其运动表现所掩盖，但这并不意味着它们的病理意义不重要。在这篇综述中，我们从临床、神经生理学、神经影像学、神经病理学、功能和分子角度，对迄今为止在 ALS 中描述的感觉和自主神经系统的受累进行了广泛描述。
