Department of Medical and Surgical Sciences, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.
Expert Rev Respir Med. 2020 May;14(5):501-510. doi: 10.1080/17476348.2020.1735365. Epub 2020 Feb 28.
: Mitogen-activated protein kinases (MAPKs) are a large family of evolutionary conserved intracellular enzymes that play a pivotal role in signaling pathways mediating the biologic actions of a wide array of extracellular stimuli.: MAPKs are implicated in most pathogenic events involved in asthma, including both inflammatory and structural changes occurring in the airways. Indeed, MAPKs are located at the level of crucial convergence points within the signal transduction networks activated by many cytokines, chemokines, growth factors, and other inducers of bronchial inflammation and remodeling such as immunoglobulin E (IgE) and oxidative stress.: Therefore, given the growing importance of MAPKs in asthma pathobiology, these signaling enzymes are emerging as key intracellular pathways whose upstream activation can be inhibited by biological drugs such as anti-cytokines and anti-IgE.
丝裂原活化蛋白激酶（MAPK）是一个进化上保守的细胞内酶大家族，在介导广泛的细胞外刺激的生物效应的信号通路中发挥关键作用。MAPK 参与哮喘涉及的大多数发病事件，包括气道中发生的炎症和结构变化。事实上，MAPK 位于许多细胞因子、趋化因子、生长因子和其他诱导支气管炎症和重塑的诱导物（如免疫球蛋白 E（IgE）和氧化应激）激活的信号转导网络中的关键汇聚点水平。因此，鉴于 MAPK 在哮喘病理生物学中的重要性不断增加，这些信号酶正在成为关键的细胞内途径，其上游激活可以被生物药物如抗细胞因子和抗 IgE 抑制。
