• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

辅助性局部抗生素羟基磷灰石生物复合材料在开放性 Gustilo Anderson IIIB 型骨折治疗中的应用

Adjuvant Local Antibiotic Hydroxyapatite Bio-Composite in the management of open Gustilo Anderson IIIB fractures. .

作者信息

Aljawadi Ahmed, Islam Amirul, Jahangir Noman, Niazi Noman, Ferguson Zak, Sephton Benjamin, Elmajee Mohammed, Reid Adam, Wong Jason, Pillai Anand

机构信息

Trauma and Orthopaedics, Manchester Foundation Trust, Southmoor Rd, Wythenshawe, Manchester, M23 9LT, UK.

ST4 Spine Department, Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, B31 2AP, UK.

出版信息

J Orthop. 2020 Jan 11;18:261-266. doi: 10.1016/j.jor.2020.01.012. eCollection 2020 Mar-Apr.

DOI:10.1016/j.jor.2020.01.012
PMID:32099272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7031137/
Abstract

BACKGROUND

This study aims to evaluate outcomes of using Adjuvant Local Antibiotic Hydroxyapatite Bio-Composite in management of Open Gustilo-Anderson IIIB Fractures.

METHODS AND RESULTS

80 patients were managed with single-stage "Fix and Flap" along with intra-operative Adjuvant Local Antibiotic Bio-Composite. Successful fracture union was achieved in 96.1% of patients, with a limb salvage rate of 96.25%. Infection rate was only 1.25%.

CONCLUSION

High union rate and very low deep infection rate can be predictably achieved in complex Open Gustilo-Anderson IIIB fractures by meticulous technique, use of local adjunctive antibiotics bio-composite and a combined ortho-plastic approach.

摘要

背景

本研究旨在评估辅助性局部抗生素羟基磷灰石生物复合材料在开放性 Gustilo-Anderson IIIB 型骨折治疗中的效果。

方法与结果

80 例患者接受了一期“固定与皮瓣”手术,并术中使用辅助性局部抗生素生物复合材料。96.1%的患者实现了骨折成功愈合,保肢率为 96.25%。感染率仅为 1.25%。

结论

通过精细的技术、使用局部辅助抗生素生物复合材料以及联合骨科 - 整形方法,在复杂的开放性 Gustilo-Anderson IIIB 型骨折中可以预期获得高愈合率和极低的深部感染率。

相似文献

1
Adjuvant Local Antibiotic Hydroxyapatite Bio-Composite in the management of open Gustilo Anderson IIIB fractures. .辅助性局部抗生素羟基磷灰石生物复合材料在开放性 Gustilo Anderson IIIB 型骨折治疗中的应用
J Orthop. 2020 Jan 11;18:261-266. doi: 10.1016/j.jor.2020.01.012. eCollection 2020 Mar-Apr.
2
Long-Term Follow-Up of Open Gustilo-Anderson IIIB Fractures Treated With an Adjuvant Local Antibiotic Hydroxyapatite Bio-Composite.采用辅助性局部抗生素羟基磷灰石生物复合材料治疗开放性 Gustilo-Anderson IIIB 型骨折的长期随访
Cureus. 2023 May 16;15(5):e39103. doi: 10.7759/cureus.39103. eCollection 2023 May.
3
One-stage combined "fix and flap" approach for complex open Gustilo-Anderson IIIB lower limbs fractures: a prospective review of 102 cases.一期联合“固定与皮瓣”治疗复杂开放性 Gustilo-Anderson ⅢB 型下肢骨折:102 例前瞻性研究
Arch Orthop Trauma Surg. 2022 Mar;142(3):425-434. doi: 10.1007/s00402-020-03705-y. Epub 2021 Jan 3.
4
The use of adjuvant local antibiotic hydroxyapatite bio-composite in the management of open Gustilo Anderson type IIIB fractures. A prospective review.辅助性局部抗生素羟基磷灰石生物复合材料在开放性 Gustilo Anderson IIIB 型骨折治疗中的应用。一项前瞻性综述。
J Orthop. 2019 Apr 9;16(3):278-282. doi: 10.1016/j.jor.2019.03.013. eCollection 2019 May-Jun.
5
Management of Gustilo Anderson III B open tibial fractures by primary fascio-septo-cutaneous local flap and primary fixation: The 'fix and shift' technique.采用一期筋膜-皮下局部皮瓣及一期固定治疗 Gustilo Anderson III B 型开放性胫骨骨折:“固定并移位”技术
Indian J Orthop. 2017 Jan-Feb;51(1):55-68. doi: 10.4103/0019-5413.197532.
6
Definitive internal fracture fixation followed by staged free flap coverage ("fix followed by flap" protocol) for open Gustilo type IIIB fractures.对于开放性Gustilo IIIB型骨折,采用确定性内固定骨折,随后分期行游离皮瓣覆盖(“先固定后皮瓣”方案)。
J Orthop Sci. 2025 Jan;30(1):142-146. doi: 10.1016/j.jos.2024.03.006. Epub 2024 Apr 10.
7
Negative pressure wound therapy for Gustilo Anderson grade IIIb open tibial fractures.负压伤口治疗用于 Gustilo Anderson Ⅲb 级开放性胫骨骨折
Indian J Orthop. 2016 Sep;50(5):536-542. doi: 10.4103/0019-5413.189604.
8
Clinical and Radiological Outcomes of Gustilo-Anderson Type IIIB Open Fractures in 125 Patients.125例 Gustilo-Anderson IIIB型开放性骨折的临床及影像学结果
Cureus. 2023 Feb 25;15(2):e35441. doi: 10.7759/cureus.35441. eCollection 2023 Feb.
9
The management of open tibial fractures in children: a retrospective case series of eight years' experience of 61 cases at a paediatric specialist centre.儿童开放性胫骨骨折的治疗:一家儿科专科中心八年61例病例的回顾性系列研究
Bone Joint J. 2017 Apr;99-B(4):544-553. doi: 10.1302/0301-620X.99B4.37855.
10
The ortho-plastic management of Gustilo grade IIIB fractures of the tibia in children: a systematic review of the literature.儿童胫骨 Gustilo ⅢB 型骨折的正塑性管理:文献系统评价。
Injury. 2009 Aug;40(8):876-9. doi: 10.1016/j.injury.2008.12.010. Epub 2009 May 5.

引用本文的文献

1
Adjuvant local antibiotic prophylaxis in Gustilo-Anderson IIIb open fractures: up to 10 years follow-up on clinical outcomes and complications.Gustilo-Anderson IIIb型开放性骨折的辅助局部抗生素预防:长达10年的临床结局和并发症随访
J Orthop Surg Res. 2025 Jun 23;20(1):610. doi: 10.1186/s13018-025-05765-5.
2
Long-Term Follow-Up of Open Gustilo-Anderson IIIB Fractures Treated With an Adjuvant Local Antibiotic Hydroxyapatite Bio-Composite.采用辅助性局部抗生素羟基磷灰石生物复合材料治疗开放性 Gustilo-Anderson IIIB 型骨折的长期随访
Cureus. 2023 May 16;15(5):e39103. doi: 10.7759/cureus.39103. eCollection 2023 May.
3
Efficacy of an Antibiotic Loaded Ceramic-Based Bone Graft Substitute for the Treatment of Infected Non-Unions.一种载抗生素的陶瓷基骨移植替代物治疗感染性骨不连的疗效
Biomedicines. 2022 Oct 8;10(10):2513. doi: 10.3390/biomedicines10102513.
4
In Vitro Evaluation of Gentamicin or Vancomycin Containing Bone Graft Substitute in the Prevention of Orthopedic Implant-Related Infections.含庆大霉素或万古霉素的骨移植替代物预防骨科植入物相关感染的体外评估
Int J Mol Sci. 2020 Dec 4;21(23):9250. doi: 10.3390/ijms21239250.

本文引用的文献

1
The use of adjuvant local antibiotic hydroxyapatite bio-composite in the management of open Gustilo Anderson type IIIB fractures. A prospective review.辅助性局部抗生素羟基磷灰石生物复合材料在开放性 Gustilo Anderson IIIB 型骨折治疗中的应用。一项前瞻性综述。
J Orthop. 2019 Apr 9;16(3):278-282. doi: 10.1016/j.jor.2019.03.013. eCollection 2019 May-Jun.
2
The effect of local antibiotic prophylaxis when treating open limb fractures: A systematic review and meta-analysis.局部抗生素预防在治疗开放性四肢骨折时的效果:一项系统评价与荟萃分析。
Bone Joint Res. 2018 Aug 4;7(7):447-456. doi: 10.1302/2046-3758.77.BJR-2018-0043.R1. eCollection 2018 Jul.
3
Antibiotic Containing Bone Substitute in Major Hip Surgery: A Long Term Gentamicin Elution Study.髋关节大手术中含抗生素骨替代物:一项庆大霉素长期洗脱研究
J Bone Jt Infect. 2018 Apr 12;3(2):68-72. doi: 10.7150/jbji.23901. eCollection 2018.
4
Incidence of infection following internal fixation of open and closed tibia fractures in India (INFINITI): a multi-centre observational cohort study.印度开放性和闭合性胫骨骨折内固定术后感染发生率(INFINITI):一项多中心观察性队列研究。
BMC Musculoskelet Disord. 2017 Apr 14;18(1):156. doi: 10.1186/s12891-017-1506-4.
5
Pharmacokinetics of gentamicin eluted from a regenerating bone graft substitute: In vitro and clinical release studies.从再生骨移植替代物中洗脱的庆大霉素的药代动力学:体外和临床释放研究。
Bone Joint Res. 2016 Sep;5(9):427-35. doi: 10.1302/2046-3758.59.BJR-2016-0108.R1.
6
Infection after fracture fixation: Current surgical and microbiological concepts.骨折固定术后感染:当前的外科及微生物学概念
Injury. 2018 Mar;49(3):511-522. doi: 10.1016/j.injury.2016.09.019. Epub 2016 Sep 11.
7
Traumatic Periprosthetic Acetabular Fracture Treated with One-Stage Exchange and Bone Reconstruction Using a Synthetic Bone Graft Substitute.采用人工骨移植替代物一期翻修及骨重建治疗创伤性髋臼周围假体周围骨折
Case Rep Orthop. 2016;2016:4160128. doi: 10.1155/2016/4160128. Epub 2016 Jun 30.
8
Improving the care of patients with severe open fractures of the tibia: the effect of the introduction of Major Trauma Networks and national guidelines.改善胫骨严重开放性骨折患者的护理:引入重大创伤网络和国家指南的效果
Bone Joint J. 2016 Mar;98-B(3):420-4. doi: 10.1302/0301-620X.98B3.35818.
9
Complete twelve month bone remodeling with a bi-phasic injectable bone substitute in benign bone tumors: a prospective pilot study.使用双相可注射骨替代物完成良性骨肿瘤的十二个月骨重塑:一项前瞻性初步研究。
BMC Musculoskelet Disord. 2015 Nov 26;16:369. doi: 10.1186/s12891-015-0828-3.
10
Infection in Orthopaedics.骨科感染
J Orthop Trauma. 2015 Dec;29 Suppl 12:S19-23. doi: 10.1097/BOT.0000000000000461.