Urban-Kowalczyk Małgorzata, Kotlicka-Antczak Magdalena, Strzelecki Dominik, Rudecka Ewa, Śmigielski Janusz
Department of Affective and Psychotic Disorders, Medical University of Łódź, Łódź, Poland.
Babiński Memorial Hospital in Łódź, Łódź, Poland.
Neuropsychiatr Dis Treat. 2019 Dec 31;15:3609-3614. doi: 10.2147/NDT.S225321. eCollection 2019.
Extensive investigations have been conducted into predictors of schizophrenia outcome. The heterogeneity of the illness implies that many factors should be taken into account. Some studies have reported the relationship between increased β-endorphin concentration and predominant negative symptoms.
We included 77 outpatients with schizophrenia and 74 healthy controls. Data referring to duration and course of illness, hospitalization number and treatment were collected on the basis of clinical interviews and medical documentation analysis. The β-endorphin concentrations were assessed once in all participants, at the onset of the study.
A chronic course of illness was found in 44 of the 77 schizophrenics. Patients with schizophrenia, especially those with a chronic course of illness, revealed significantly higher β-endorphin concentrations than those with an episodic course and controls (mean 29.70 vs 19.86 pmol/L; =0.0001). Increased levels of β-endorphin were related to longer duration of illness (=0.294, =0.009) and frequent psychiatric hospitalization (=0.346, =-0.002).
Endorphins may be potential biological predictors of persistent negative symptoms and final outcome in schizophrenia.
针对精神分裂症预后的预测因素已开展了广泛研究。该疾病的异质性意味着应考虑诸多因素。一些研究报告了β-内啡肽浓度升高与显著阴性症状之间的关系。
我们纳入了77名精神分裂症门诊患者和74名健康对照者。基于临床访谈和医疗文档分析，收集了有关疾病持续时间和病程、住院次数及治疗情况的数据。在研究开始时，对所有参与者进行了一次β-内啡肽浓度评估。
77名精神分裂症患者中有44名病程呈慢性。精神分裂症患者，尤其是病程呈慢性的患者，其β-内啡肽浓度显著高于病程呈发作性的患者及对照者（平均29.70对19.86皮摩尔/升；P = 0.0001）。β-内啡肽水平升高与疾病持续时间延长（P = 0.294，P = 0.009）及频繁的精神科住院治疗（P = 0.346，P = -0.002）相关。
内啡肽可能是精神分裂症持续阴性症状和最终预后的潜在生物学预测指标。
