甲氨蝶呤在银屑病表皮中的摄取。

Methotrexate uptake by psoriatic epidermis.

作者信息

Taylor J R, Halprin K M

出版信息

Br J Dermatol. 1977 Feb;96(2):167-70. doi: 10.1111/j.1365-2133.1977.tb12539.x.

DOI:10.1111/j.1365-2133.1977.tb12539.x

PMID:320999

Abstract

Psoriatic epidermis has been shown to be more sensitive to the effects of methotrexate than normal epidermis. One possible explanation for this observation is more rapid active transport of methotrexate into psoriatic cells. This study compares the uptake of methotrexate by normal and psoriatic epidermis and demonstrates the influence of extracellular pH on this process. Methotrexate uptake was not found to be greater in psoriatic epidermis than normal. A possible explanation for this unexpected finding is discussed.

摘要

银屑病表皮已被证明比正常表皮对甲氨蝶呤的作用更敏感。对此观察结果的一种可能解释是甲氨蝶呤向银屑病细胞的主动转运更快。本研究比较了正常表皮和银屑病表皮对甲氨蝶呤的摄取，并证明了细胞外pH对这一过程的影响。未发现银屑病表皮对甲氨蝶呤的摄取比正常表皮更多。讨论了这一意外发现的可能解释。