Roelfzema H, Bergers M, Van Erp P E, Gommans J M, Mier P D
Br J Dermatol. 1981 Jun;104(6):635-40. doi: 10.1111/j.1365-2133.1981.tb00749.x.
We report the uptake of four labelled sugars by keratinocytes isolated from normal epidermis, psoriatic 'uninvolved' skin and psoriatic lesions. Our findings include the following: (1) The rate of uptake of all sugars by the psoriatic lesion is increased. (2) This abnormally high uptake diminishes dramatically during 22 h incubation in vitro. (3) There is a striking abnormality in the metabolism of fucose by psoriatic keratinocytes; our data suggest an increased rate of incorporation of fucose into glycoconjugates.
我们报告了从正常表皮、银屑病“未受累”皮肤和银屑病皮损中分离出的角质形成细胞对四种标记糖的摄取情况。我们的研究结果如下：（1）银屑病皮损对所有糖的摄取速率均增加。（2）在体外培养22小时期间，这种异常高的摄取显著降低。（3）银屑病角质形成细胞对岩藻糖的代谢存在显著异常；我们的数据表明岩藻糖掺入糖结合物的速率增加。
