Zheng Wan-Shan, Hu Xiao-Qian, Wang Yan-Ling, Cao Bin
School of Medicine, Xiamen University, Xiamen 361102, China.
Guangzhou Institute of Obstetrics & Gynaecology, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
Sheng Li Xue Bao. 2020 Feb 25;72(1):115-124.
Placenta serves as a temporary fetal organ, which mediates maternal-fetal crosstalk and intrauterine fetal growth. Placental defensive barrier is a fundamental physiological function, which balances maternal immune tolerance to the fetus and resistance to pathogens. This review summarizes the latest research progress on the mechanisms of placental barrier formation from the view of placental development. Recent discoveries have shed light on the cellular and molecular properties of placental defensive mechanisms in syncytiotrophoblast, including autophagy, exosome mediated anti-pathogenic pathways, cell-cell junctions and cytoskeleton networks. We also present an overview of placental barrier dysfunction and its implications in intrauterine TORCH infections.
胎盘是一个临时的胎儿器官，介导母胎间的相互作用和子宫内胎儿的生长。胎盘防御屏障是一项基本的生理功能，它平衡了母体对胎儿的免疫耐受和对病原体的抵抗力。本文综述从胎盘发育角度对胎盘屏障形成机制的最新研究进展。最近的发现揭示了合体滋养层细胞中胎盘防御机制的细胞和分子特性，包括自噬、外泌体介导的抗病原体途径、细胞间连接和细胞骨架网络。我们还概述了胎盘屏障功能障碍及其在子宫内TORCH感染中的影响。
