阿尔茨海默病、多发梗死性痴呆及混合性痴呆患者脑胆碱乙酰转移酶活性的比较

A comparison of brain choline acetyltransferase activity in Alzheimer's disease, multi-infarct dementia, and combined dementia.

作者信息

Rinne J O, Säkö E, Paljärvi L, Mölsä P K, Rinne U K

机构信息

Department of Neurology, University of Turku, Finland.

出版信息

J Neural Transm. 1988;73(2):121-8. doi: 10.1007/BF01243383.

DOI:10.1007/BF01243383

PMID:3210004

Abstract

Brain choline acetyltransferase (ChAT) activity was determined in 43 patients with Alzheimer's disease (AD), 14 with multi-infarct dementia (MID), and 15 with combined dementia (CD) and in 53 age-matched controls. The activity of ChAT declined in the hippocampus, temporal and frontal cortex in patients with AD and CD compared to the controls. In the AD group the reduced activity of ChAT in all brain areas was associated with a greater number of cortical neurofibrillary tangles. The degree of dementia had a negative correlation with the activity of ChAT in the frontal cortex in both AD and CD patients. The activity of ChAT in the temporal cortex of CD patients was negatively associated with the cortical tangle counts. In contrast, the activity of ChAT and MID patients was not essentially different from that of the controls. Neither did the various clinical and neuropathological variables show any significant correlation with ChAT activity in MID patients. Thus, in this study the reduction in the activity of ChAT seems to be associated with Alzheimer-type pathology but not with dementia due to vascular changes.

摘要

对43例阿尔茨海默病（AD）患者、14例多发梗死性痴呆（MID）患者、15例混合性痴呆（CD）患者以及53例年龄匹配的对照者测定了脑胆碱乙酰转移酶（ChAT）活性。与对照者相比，AD和CD患者海马、颞叶及额叶皮质的ChAT活性降低。在AD组中，所有脑区ChAT活性降低与更多的皮质神经原纤维缠结相关。痴呆程度在AD和CD患者中均与额叶皮质ChAT活性呈负相关。CD患者颞叶皮质ChAT活性与皮质缠结计数呈负相关。相比之下，MID患者的ChAT活性与对照者无本质差异。各种临床和神经病理学变量在MID患者中也均未显示与ChAT活性有任何显著相关性。因此，在本研究中，ChAT活性降低似乎与阿尔茨海默型病理改变相关，而与血管性改变所致痴呆无关。