脊髓 Wnt 信号通路在 HIV 相关神经性疼痛中的作用。
The Role of the Spinal Wnt Signaling Pathway in HIV-Related Neuropathic Pain.
机构信息
Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
Clinical Laboratory of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
出版信息
Cell Mol Neurobiol. 2020 Oct;40(7):1075-1085. doi: 10.1007/s10571-020-00805-6. Epub 2020 Feb 25.
Abstract
Human immunodeficiency virus (HIV)-related neuropathic pain includes HIV-induced neuropathic pain (HNP) and antiretroviral therapy-induced neuropathic pain (ART-NP). A significant amount of evidence from the past few years has shown that the development of HIV-related neuropathic pain is closely related to the activation of the Wnt signaling pathway in the spinal cord. This review summarizes the function of the spinal Wnt signaling pathway in HIV-induced neuropathic pain, focusing on the role of the spinal Wnt signaling pathway in HNP, and provides a theoretical basis for further studies and the exploration of new target drugs.
摘要
人类免疫缺陷病毒（HIV）相关的神经性疼痛包括 HIV 引起的神经性疼痛（HNP）和抗逆转录病毒治疗引起的神经性疼痛（ART-NP）。过去几年的大量证据表明，HIV 相关神经性疼痛的发展与脊髓中 Wnt 信号通路的激活密切相关。本综述总结了脊髓 Wnt 信号通路在 HIV 诱导的神经性疼痛中的作用，重点介绍了脊髓 Wnt 信号通路在 HNP 中的作用，为进一步的研究和新靶标药物的探索提供了理论依据。
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