Pérez-Carbonell L, Higgins S, Koutroumanidis M, Leschziner G
Guy's and St Thomas' NHS Foundation Trust, London, Reino Unido.
Rev Neurol. 2020 Mar 1;70(5):179-182. doi: 10.33588/rn.7005.2019332.
Vagus nerve stimulation (VNS) is indicated in cases of refractory epilepsy. Its side effects are frequently minor, however, breathing disturbances during sleep have been previously reported.
Our three cases are representative of sleep-disordered breathing that occurred as a consequence of VNS activity in patients with refractory epilepsy. Sleep apnoea was observed in two patients and stridor in one patient.
Given the high prevalence of sleep apnoea-hypopnoea syndrome in patients with refractory epilepsy, implantation of VNS should be ideally preceded by an assessment of the breathing during sleep. Furthermore, sleep-disordered breathing should be considered as a rare complication of VNS, and sleep apnoea should be investigated alongside data regarding VNS firing.
迷走神经刺激（VNS）适用于难治性癫痫病例。其副作用通常较小，然而，此前已有睡眠期间呼吸障碍的报道。
我们的三例病例代表了难治性癫痫患者因VNS活动而发生的睡眠呼吸障碍。两名患者出现睡眠呼吸暂停，一名患者出现喘鸣。
鉴于难治性癫痫患者中睡眠呼吸暂停低通气综合征的高患病率，理想情况下，在植入VNS之前应先评估睡眠期间的呼吸情况。此外，睡眠呼吸障碍应被视为VNS的一种罕见并发症，并且应结合VNS放电数据对睡眠呼吸暂停进行调查。
