Vatnehol Svein Are Sirirud, Hol Per Kristian, Bjørnerud Atle, Amiry-Moghaddam Mahmood, Haglerød Camilla, Storås Tryggve Holck
Faculty of Medicine, University of Oslo, Oslo, Norway.
The Intervention Centre, Oslo University Hospital, Oslo, Norway.
J Magn Reson Imaging. 2020 Sep;52(3):720-728. doi: 10.1002/jmri.27104. Epub 2020 Feb 25.
This project was funded by the Research Council of Norway.
Oxygen uptake through the gastrointestinal tract after oral administration of oxygenated water in humans is not well studied and is debated in the literature. Due to the paramagnetic properties of oxygen and deoxyhemoglobin, MRI as a technique might be able to detect changes in relaxometry values caused by increased oxygen levels in the blood.
To assess whether oxygen dissolved in water is absorbed from the gastrointestinal tract and transported into the bloodstream after oral administration.
A randomized, double-blinded, placebo-controlled crossover trial.
POPULATION/SUBJECTS: Thirty healthy male volunteers age 20-35.
FIELD STRENGTH/SEQUENCE: 3T/Modified Look-Locker inversion recovery (MOLLI) T -mapping and multi fast field echo (mFFE) T *-mapping.
Each volunteer was scanned in two separate sessions. T and T * maps were acquired repeatedly covering the hepatic portal vein (HPV) and vena cava inferior (VCI, control vein) before and after intake of oxygenated or control water. Assessments were done by placing a region of interest in the HPV and VCI.
A mixed linear model was performed to the compare control vs. oxygen group.
Drinking caused a mean 1.6% 95% CI (1.1-2.0% P < 0.001) increase in T of HPV blood and water oxygenation attributed another 0.70% 95% confidence interval (CI) (0.07-1.3% P = 0.028) increase. Oxygenation did not change T in VCI blood. Mean T * increased 9.6% 95% CI (1.7-17.5% P = 0.017) after ingestion of oxygenated water and 1.2% 95% CI (-4.3-6.8% P = 0.661) after ingestion of control water. The corresponding changes in VCI blood were not significant.
Ingestion of water caused changes in T and T * of HPV blood compatible with dilution due to water absorption. The effects were enhanced by oxygen. Assessment of oxygen enrichment of HPV blood was not possible due to the dilution effect.
2 TECHNICAL EFFICACY STAGE: 2 J. Magn. Reson. Imaging 2020;52:720-728.
本项目由挪威研究理事会资助。
人体口服含氧水后通过胃肠道摄取氧气的情况尚未得到充分研究，文献中存在争议。由于氧气和脱氧血红蛋白的顺磁特性，MRI作为一种技术或许能够检测出血液中氧气水平升高引起的弛豫测量值变化。
评估口服后溶解在水中的氧气是否从胃肠道吸收并进入血液循环。
一项随机、双盲、安慰剂对照的交叉试验。
30名年龄在20 - 35岁的健康男性志愿者。
场强/序列：3T/改良Look-Locker反转恢复（MOLLI）T映射和多快速场回波（mFFE）T*映射。
每位志愿者在两个单独的时间段进行扫描。在摄入含氧水或对照水之前和之后，反复采集覆盖肝门静脉（HPV）和下腔静脉（VCI，对照静脉）的T和T*图。通过在HPV和VCI中放置感兴趣区域进行评估。
采用混合线性模型比较对照组和氧气组。
饮水导致HPV血液的T值平均增加1.6% 95%置信区间（1.1 - 2.0%，P < 0.001），水的氧合作用又使T值增加0.70% 95%置信区间（0.07 - 1.3%，P = 0.028）。氧合作用未改变VCI血液中的T值。摄入含氧水后平均T*值增加9.6% 95%置信区间（1.7 - 17.5%，P = 0.017），摄入对照水后增加1.2% 95%置信区间（ - 4.3 - 6.8%，P = 0.661）。VCI血液中的相应变化不显著。
摄入水导致HPV血液的T和T*值发生变化，这与因水吸收导致的稀释相符。氧气增强了这些效应。由于稀释效应，无法评估HPV血液中的氧富集情况。
2 技术效能阶段：2 《磁共振成像杂志》2020年；52:720 - 728 。
