Yunnan Provincial Center for Disease Control and Prevention, Kunming, China.
Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Institute, Capital Medical University, Beijing, China.
Am J Trop Med Hyg. 2020 Apr;102(4):728-730. doi: 10.4269/ajtmh.19-0533.
In this study, we report an investigation of a tuberculosis (TB) outbreak in a high school in China. Eleven students with active TB were identified. A culture-negative 17-year-old girl was considered as index case affected by pulmonary and meningeal TB. Screening results indicated latent TB in 32.8% of the students in the classroom of index case, whereas a significantly decreased prevalence of TB infection was found among students on the same floor, ranging from 1.3 to 8.2%. Genotyping revealed that all the (MTB) isolates belonged to Beijing spoligotype international types 1 (SIT1). In conclusion, a diagnostic delay for the culture-negative index case played an important role in the transmission of Beijing genotype MTB strain in the boarding school in Yunnan. The separate locations of classrooms and sufficient air ventilation contributed to the significant difference in proportions of TB infection between classmates and other students in this outbreak.
在这项研究中，我们报告了一起在中国一所高中发生的结核病（TB）暴发事件。共发现 11 名活动性肺结核学生。一名培养阴性的 17 岁女孩被认为是患有肺和脑膜结核的原发病例。筛查结果显示，原发病例所在教室的 32.8%学生存在潜伏性结核病，而在同一楼层的学生中，结核病感染的患病率显著下降，范围为 1.3%至 8.2%。基因分型显示，所有（MTB）分离株均属于北京 spoligotype 国际型 1（SIT1）。总之，培养阴性原发病例的诊断延迟是导致云南寄宿学校中北京基因型 MTB 菌株传播的重要原因。教室的单独位置和充足的空气通风有助于解释此次暴发中同班同学和其他学生之间结核病感染比例的显著差异。
