Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Department of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, China.
Front Public Health. 2022 Aug 23;10:978159. doi: 10.3389/fpubh.2022.978159. eCollection 2022.
During the COVID-19 pandemic in 2020, a tuberculosis outbreak occurred in a university in eastern China, with 4,488 students and 421 staff on the campus. A 19-year-old student was diagnosed in August 2019. Later, the first round of screening was initiated among close contacts, but no active cases were found. Till September 2020, four rounds of screening were performed. Four rounds of screening were conducted on September 9, November 8, November 22-25 in 2019 and September 2020, with 0, 5, 0 and 43 cases identified, respectively. A total of 66 active tuberculosis were found in the same university, including 4 sputum culture-positive and 7 sputum smear-positive. The total attack rate of active tuberculosis was 1.34% (66/4909). The whole-genome sequencing showed that the isolates belonged to the same L2 sub-specie and were sensitive to all tested antituberculosis drugs. Delay detection, diagnosis and report of cases were the major cause of this university tuberculosis epidemic. More attention should be paid to the asymptomatic students in the index class. After the occurrence of tuberculosis cases in schools, multiple rounds of screening should be carried out, and preventive therapy should be applied in a timely manner.
2020 年新冠肺炎疫情期间，中国东部一所大学发生肺结核疫情，校园内有 4488 名学生和 421 名教职员工。一名 19 岁学生于 2019 年 8 月确诊。随后，对密切接触者进行了首轮筛查，但未发现活动病例。到 2020 年 9 月，共进行了四轮筛查。2019 年 9 月 9 日、11 月 8 日、11 月 22 日至 25 日和 2020 年 9 月共进行了四轮筛查，分别发现 0、5、0 和 43 例，共发现 66 例活动性肺结核，其中 4 例痰培养阳性，7 例痰涂片阳性。同一所大学的活动性肺结核总发病率为 1.34%（66/4909）。全基因组测序显示，分离株属于同一 L2 亚种，对所有检测的抗结核药物均敏感。病例的延迟检测、诊断和报告是导致此次大学肺结核疫情的主要原因。应更加关注索引班级的无症状学生。学校发生结核病病例后，应进行多轮筛查，并及时应用预防性治疗。
