Jia Nan, Rosella Erica, Juère Estelle, Pouliot Roxane, Kleitz Freddy, Greener Jesse
Département de Chimie, Université Laval, 1045 avenue de la médecine, Québec, G1V 0A6, Canada.
Department of Inorganic Chemistry - Functional Materials, Faculty of Chemistry, University of Vienna, Währinger Straße 42, 1090 Vienna, Austria.
Lab Chip. 2020 Mar 17;20(6):1066-1071. doi: 10.1039/d0lc00039f.
Physically crosslinked microscale biomembranes synthesized from pure chitosan are designed and demonstrated for pH-triggered release of embedded functionalized mesoporous silica nanoparticles. Nanoparticle-loaded membranes are formed in a microfluidic channel at the junction between accurately controlled co-flowing streams to achieve highly tuneable membrane properties. After formation, the loaded membranes remain stable until contact with physiological acidic conditions, resulting in controlled nanoparticle release. Furthermore, nanoparticle-loaded membranes with complex layered architectures are synthesized using different flow schemes, thus enabling customized nanoparticle release profiles. These novel materials are well-suited for integration within small medical devices as well as off-chip applications.
由纯壳聚糖合成的物理交联微尺度生物膜被设计并用于证明其对嵌入的功能化介孔二氧化硅纳米颗粒的pH触发释放。负载纳米颗粒的膜在微流控通道中精确控制的共流流股之间的交界处形成，以实现高度可调的膜性能。形成后，负载的膜在与生理酸性条件接触之前保持稳定，从而实现纳米颗粒的可控释放。此外，使用不同的流动方案合成了具有复杂分层结构的负载纳米颗粒的膜，从而实现定制的纳米颗粒释放曲线。这些新型材料非常适合集成在小型医疗设备以及芯片外应用中。
