Baby Thejus, Liu Yun, Yang Guangze, Chen Dong, Zhao Chun-Xia
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, Queensland 4072, Australia.
Institute of Process Equipment, College of Energy Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
J Colloid Interface Sci. 2021 Jul 15;594:474-484. doi: 10.1016/j.jcis.2021.03.035. Epub 2021 Mar 15.
Polymer nanoparticles (NPs) have attracted significant interest in the past years for drug delivery and triggered release. However, it remains a significant challenge to produce polymer NPs with controlled properties and tunable drug loading. Traditional nanoprecipitation often leads to low drug loading. This study reports the development of a new microfluidic nanoprecipitation approach for making polymer NPs with tunable drug loading up to 50%. The synthesized curcumin-loaded shellac NPs remain very stable for the period of our experiments (10 days) under acidic conditions (pH 4.5), but release the payload at neutral pH in a sustained manner. This work provides a new strategy for making drug-loaded polymer NPs with tunable drug loading and triggered release.
在过去几年中，聚合物纳米颗粒（NPs）在药物递送和触发释放方面引起了极大的关注。然而，制备具有可控性质和可调药物负载量的聚合物纳米颗粒仍然是一项重大挑战。传统的纳米沉淀法往往导致药物负载量较低。本研究报告了一种新的微流控纳米沉淀方法的开发，该方法用于制备药物负载量可调高达50%的聚合物纳米颗粒。在我们的实验期间（10天），合成的负载姜黄素的紫胶纳米颗粒在酸性条件（pH 4.5）下保持非常稳定，但在中性pH下以持续的方式释放其负载物。这项工作为制备具有可调药物负载量和触发释放功能的载药聚合物纳米颗粒提供了一种新策略。
