Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Vet Res. 2020 Feb 26;51(1):29. doi: 10.1186/s13567-020-00744-6.
Echinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminonicotinamide (6-AN) exhibited considerable in vitro effects against both larval- and adult-stage of E. granulosussensu stricto (s. s.) and E. multilocularis. The combination of LND and 6-AN exhibited a significantly higher activity than the single drug treatment. These results highlight the therapeutic potential of LND, 6-AN and the combination of LND and 6-AN for the treatment of echinococcosis.
包虫病是一种由细粒棘球绦虫属的绦虫引起的人畜共患疾病，具有重要的医学和兽医学意义。迫切需要开发治疗包虫病的新药。在这项研究中，我们证明了洛尼定（LND）和 6-氨基烟酰胺（6-AN）对细粒棘球蚴（s. s.）和泡状棘球蚴的幼虫期和成虫期均具有显著的体外作用。LND 和 6-AN 的联合用药比单一药物治疗具有更高的活性。这些结果突出了 LND、6-AN 以及 LND 和 6-AN 联合用药治疗包虫病的治疗潜力。
