School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, Guangzhou Key Laboratory of Tumor Immunology Research, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Vet Res. 2019 Jan 14;50(1):3. doi: 10.1186/s13567-019-0621-7.
Echinococcosis is a zoonotic infection caused by cestode species of the genus Echinococcus, with limited treatment options. It is urgent to develop new anti-hydatid agent. In this paper, we reported anacardic acid (AA), a natural product isolated from the Brazilian cashew-nut shell liquid, which presented a high activity against metacestodes of Echinococcus multilocularis (E. multilocularis) and Echinococcus granulosus sensu stricto (E. granulosus s.s.) in vitro and in vivo. AA exerted a better efficacy on E. granulosus s.s. protoscoleces and E. multilocularis metacestodes than that of albendazole (ABZ) and dihydroartemisinin (DHA) in vitro, and an inhibition on the growth of Echinococcus metacestode as effective as ABZ in vivo. Moreover, we also found that one of the mechanisms of AA against Echinococcus could be the suppression of angiogenesis on/in the metacestode mass through inhibiting vascular endothelial growth factor (VEGF)-induced signalling pathways. This work finds that AA is a new promising potential candidate drug for echinococcosis treatment.
棘球蚴病是一种由细粒棘球绦虫属的绦虫引起的人畜共患感染，治疗选择有限。因此，迫切需要开发新的抗包虫药物。本文报道了一种来自巴西腰果壳液的天然产物，漆酚（AA），它对多房棘球蚴（E. multilocularis）和细粒棘球蚴亚种（E. granulosus s.s.）的原头蚴在体外和体内均具有高活性。AA 在体外对细粒棘球蚴亚种原头节和多房棘球蚴原头蚴的疗效优于阿苯达唑（ABZ）和双氢青蒿素（DHA），在体内对包虫蚴生长的抑制作用与 ABZ 相当。此外，我们还发现 AA 抑制血管内皮生长因子（VEGF）诱导的信号通路，从而抑制包虫蚴内/外血管生成，这可能是 AA 抗包虫的机制之一。这项工作发现 AA 是一种治疗包虫病的有前途的新型候选药物。
