基于天然化学连接方法的双模态肽成像探针的合成的创新方法。
An innovative approach for the synthesis of dual modality peptide imaging probes based on the native chemical ligation approach.
机构信息
Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Centro di Imaging Molecolare, Università degli Studi di Torino, Via Nizza 52, 10126, Torino (TO), Italy.
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134 Napoli (NA), Italy.
出版信息
Chem Commun (Camb). 2020 Mar 25;56(24):3500-3503. doi: 10.1039/c9cc09980h. Epub 2020 Feb 26.
Peptide-targeting probes tagged with optical imaging and PET reporters may find applications in innovative diagnostic procedures and image-guided surgeries. The reported synthesis procedure is of general applicability to obtain dual imaging probes using fully unprotected moieties with a selective and rapid chemistry based on native chemical ligation.
用光学成像和正电子发射断层扫描（PET）报告器标记的肽靶向探针可能会在创新的诊断程序和图像引导手术中找到应用。所报道的合成程序具有通用性，可使用完全未保护的部分获得双重成像探针，并基于天然化学连接进行选择性和快速的化学。
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