Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.
Top Curr Chem (Cham). 2023 Nov 22;381(6):35. doi: 10.1007/s41061-023-00445-6.
The desire to create biomolecules modified with functionalities that go beyond nature's toolbox has resulted in the development of biocompatible and selective methodologies and reagents, each with different scope and limitations. In this overview, we highlight recent advances in the field of bioconjugation from 2016 to 2023. First, (metal-mediated) protein functionalization by exploiting the specific reactivity of amino acids will be discussed, followed by novel bioorthogonal reagents for bioconjugation of modified biomolecules.
人们渴望创造具有超越自然工具箱功能的生物分子，这导致了生物相容性和选择性方法和试剂的发展，每种方法和试剂都有不同的范围和局限性。在这篇综述中，我们重点介绍了 2016 年至 2023 年生物共轭领域的最新进展。首先，我们将讨论利用氨基酸的特异性反应性进行（金属介导的）蛋白质功能化，然后讨论用于修饰生物分子的生物正交试剂的新进展。
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