College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China.
Org Biomol Chem. 2020 Mar 14;18(10):1940-1948. doi: 10.1039/d0ob00086h. Epub 2020 Feb 26.
A visible-light-promoted decarboxylative acyl radical acylation/cyclization cascade reaction of N-methacryloylbenzamides for accessing acylated isoquinoline-1,3(2H,4H)-dione derivatives was described. In this report, α-keto acids were used for generating acyl radicals and inducing radical acylations. This protocol features mild reaction conditions, operational practicality and a broad substrate scope.
本文描述了一种可见光促进的 N-丙烯酰基苯甲酰胺的脱羧酰基自由基酰化/环化级联反应，用于构建酰基异喹啉-1,3(2H,4H)-二酮衍生物。在本报告中，α-酮酸被用于生成酰基自由基并引发自由基酰化反应。该方法具有反应条件温和、操作实用性强和底物适用范围广等特点。
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