Natural Products Research Centre, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Molecules. 2023 Jan 17;28(3):923. doi: 10.3390/molecules28030923.
Dess-Martin periodinane (DMP) is a broadly applicable oxidant in chemical synthesis. In this work, an efficient and convenient synthesis of -substituted isoquinolinone derivatives mediated by DMP was achieved through the oxidative coupling reaction of functionalized isoquinoline with readily available benzyl bromide, which is a metal-free, mild, and practical method for synthesizing isoquinoline-1,3-dione or isoquinoline-1,3,4-trione derivatives in excellent yields. The HO-labeling experiment was performed to gain insight into the possible mechanism for this reaction.
戴斯-马丁过碘烷（DMP）是一种广泛应用于化学合成的氧化剂。在这项工作中，通过功能化异喹啉与易得的溴化苄的氧化偶联反应，实现了 DMP 介导的 -取代异喹啉酮衍生物的高效、便捷合成，这是一种无金属、温和且实用的方法，可在优异产率下合成异喹啉-1,3-二酮或异喹啉-1,3,4-三酮衍生物。进行了 HO 标记实验以深入了解该反应的可能机制。
