阿尔茨海默病和帕金森痴呆通过认知标志物加以区分。
Alzheimer's Disease and Parkinson Dementia Distinguished by Cognitive Marker.
机构信息
Human Cognitive Neuroscience, Psychology Department, University of Edinburgh, UK.
School of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK.
出版信息
Arch Clin Neuropsychol. 2021 Apr 21;36(3):307-315. doi: 10.1093/arclin/acz082.
BACKGROUND
Temporary memory binding (TMB) has been shown to be specifically affected by Alzheimer's disease (AD) when it is assessed via free recall and titrating the task demands to equate baseline performance across patients.
METHODS
Patients with Parkinson's disease (PD) were subdivided into patients with and without cognitive impairment and compared with AD and amnestic mild cognitive impairment (aMCI) patients on their performance on the TMB.
RESULTS
The results show that only patients with AD dementia present with impaired TMB performance. Receiver operating characteristic curve analyses showed that TMB holds high sensitivity and specificity for aMCI and AD relative to PD groups and healthy controls.
CONCLUSION
The TMB is sensitive to the neurodegenerative mechanisms leading to AD dementia but not to those underpinning PD dementia. As such, TMB task can aid the differential diagnosis of these common forms of dementia.
背景
通过自由回忆评估并调整任务需求以使患者的基线表现均等化时，临时记忆绑定（TMB）已被证明在阿尔茨海默病（AD）中受到特别影响。
方法
将帕金森病（PD）患者分为有认知障碍和无认知障碍的患者，并在 TMB 上与 AD 和遗忘型轻度认知障碍（aMCI）患者进行比较。
结果
结果表明，只有 AD 痴呆患者的 TMB 表现受损。接收者操作特征曲线分析表明，与 PD 组和健康对照组相比，TMB 对 aMCI 和 AD 具有较高的敏感性和特异性。
结论
TMB 对导致 AD 痴呆的神经退行性机制敏感，但对导致 PD 痴呆的机制不敏感。因此，TMB 任务可以帮助这些常见形式的痴呆症的鉴别诊断。
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