From the Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX (Y.H.S., S.A.L.).
Department of Cardiovascular Surgery, Texas Heart Institute, Houston (Y.H.S., S.A.L.).
Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):e37-e46. doi: 10.1161/ATVBAHA.120.313991. Epub 2020 Feb 26.
The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In response to changes in the biomechanical environment, aortic cells and extracellular matrix modulate their structure and functions to increase aortic wall strength and meet the hemodynamic demand. Compromise in the structural and functional integrity of aortic components leads to aortic degeneration, biomechanical failure, and the development of aortic aneurysms and dissections (AAD). A better understanding of the molecular pathogenesis of AAD will facilitate the development of effective medications to treat these conditions. Here, we summarize recent findings on AAD published in . In this issue, we focus on the dynamics of aortic cells and extracellular matrix in AAD; in the next issue, we will focus on the role of signaling pathways in AAD.
主动脉壁由高度动态的细胞群体和细胞外基质组成。为了应对生物力学环境的变化，主动脉细胞和细胞外基质会调节它们的结构和功能，以增加主动脉壁的强度并满足血液动力学需求。主动脉成分的结构和功能完整性受损会导致主动脉退行性变、生物力学衰竭以及主动脉瘤和夹层（AAD）的发展。更好地了解 AAD 的分子发病机制将有助于开发治疗这些疾病的有效药物。在这里，我们总结了在 上发表的有关 AAD 的最新研究结果。本期我们重点介绍 AAD 中主动脉细胞和细胞外基质的动态变化；下期我们将重点介绍信号通路在 AAD 中的作用。
