Li Zhuofan, Gong Ze, Li Weihao, Chen Yanghui, Dai Rongbo, Yang Shiyu, Chen Yufei, Yu Fang, Fu Yi, Li Wei, Wang Dao Wen, Jia Yiting, Kong Wei
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Hwamei College of Life and Health Sciences, Zhejiang Wanli University, Ningbo, China.
JACC Basic Transl Sci. 2025 Jul 17;10(8):101329. doi: 10.1016/j.jacbts.2025.101329.
Thoracic aortic dissection (TAD) is a life-threatening cardiovascular disease that is associated with high morbidity and mortality. The prevailing challenge in TAD monitoring and diagnosis is the lack of novel biomarkers. A significant and sustained reduction in plasma cartilage oligomeric matrix protein (COMP) levels was observed through a case control analysis conducted in 362 TAD patients and 136 controls. The protective role of COMP was assessed in two TAD mouse models. These data suggested that a decreased plasma COMP level might serve as a novel biomarker for TAD progression and COMP could suppress the development of TAD and ameliorate vascular pathogenesis.
胸主动脉夹层（TAD）是一种危及生命的心血管疾病，具有高发病率和死亡率。TAD监测和诊断面临的主要挑战是缺乏新型生物标志物。通过对362例TAD患者和136例对照进行病例对照分析，观察到血浆软骨寡聚基质蛋白（COMP）水平显著且持续降低。在两种TAD小鼠模型中评估了COMP的保护作用。这些数据表明，血浆COMP水平降低可能作为TAD进展的新型生物标志物，并且COMP可以抑制TAD的发展并改善血管发病机制。
