Bindschaedler C, Leong K, Mathiowitz E, Langer R
Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge 02139.
J Pharm Sci. 1988 Aug;77(8):696-8. doi: 10.1002/jps.2600770811.
A novel process based on solvent extraction was developed to produce drug-loaded polyanhydride microspheres for controlled-release applications. The technique consists of adding a chloroform solution of polyanhydride and drug into a stirred silicone oil phase containing suspended droplets of surfactant. No chemical reaction, heating, nor contact with water was required in this process. The microspheres produced were capable of releasing various dyes for prolonged periods of time.
