Berman Institute of Bioethics.
School of Medicine.
Curr Opin HIV AIDS. 2020 May;15(3):180-184. doi: 10.1097/COH.0000000000000618.
Achieving a cure for HIV or hepatitis B virus (HBV) is expected to have a range of salutary effects including eliminating the need for continued treatments, minimizing risk to sexual and injecting partners, reducing prevalence, and decreasing stigma. Nevertheless, conducting research to achieve such laudable goals is necessarily associated with a broad set of ethical challenges. This review aims at describing key findings from selected peer-reviewed literature published in the last 2 years (2018-2019) that enhance understanding of some of these issues.
A variety of ethical issues in HIV cure research have been informed by recent conceptual and empirical scholarship. These include: analytical treatment interruptions; attitudes towards participation; responsibilities to nonparticipants; consent and terminology; and selected other issues.
Understanding of the ethical issues in HIV cure research has been enhanced by sustained normative and empirical scholarship with a range of stakeholders. This work has crucial implications for HBV cure research, but there is also a pressing need for directed work on HBV cure research. In both HIV and HBV cure research, such scholarship promises to help ensure that critically important research efforts are ethically sound.
治愈 HIV 或乙型肝炎病毒（HBV）预计将产生一系列有益影响，包括消除对持续治疗的需求、最大限度地降低性伴侣和注射毒品者的风险、降低流行率和减少污名。然而，开展实现这些崇高目标的研究必然会涉及一系列广泛的伦理挑战。本综述旨在描述过去 2 年（2018-2019 年）发表的选定同行评议文献中的关键发现，以增强对其中一些问题的理解。
最近的概念和实证研究为 HIV 治愈研究中的各种伦理问题提供了信息。这些问题包括：分析性治疗中断；对参与的态度；对非参与者的责任；同意和术语；以及其他一些问题。
规范性和实证研究以及一系列利益相关者对 HIV 治愈研究中的伦理问题的理解不断增强。这项工作对 HBV 治愈研究具有至关重要的意义，但也迫切需要针对 HBV 治愈研究开展定向工作。在 HIV 和 HBV 治愈研究中，此类研究有望帮助确保重要的研究工作符合伦理规范。
