Ziental Daniel, Czarczynska-Goslinska Beata, Mlynarczyk Dariusz T, Glowacka-Sobotta Arleta, Stanisz Beata, Goslinski Tomasz, Sobotta Lukasz
Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.
Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.
Nanomaterials (Basel). 2020 Feb 23;10(2):387. doi: 10.3390/nano10020387.
Metallic and metal oxide nanoparticles (NPs), including titanium dioxide NPs, among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO NPs themselves, as well as their composites and combinations with other molecules or biomolecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO nanoparticles, leading to hybrid materials. These nanostructures can reveal increased light absorption, allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer and antimicrobial therapies, many approaches utilizing titanium dioxide were tested. Results of selected studies presenting the scope of potential uses are discussed in this review.
金属及金属氧化物纳米颗粒（NPs），包括二氧化钛纳米颗粒，在聚合物纳米颗粒、脂质体、胶束、量子点、树枝状大分子或富勒烯中，因其在新型医学疗法中的潜在应用而变得越来越重要。二氧化钛（氧化钛（IV）、二氧化钛、TiO₂）是一种无机化合物，其最近在科学上引起关注归因于光活性。在水性介质中用紫外线照射后，TiO₂会产生一系列活性氧（ROS）。产生ROS并因此诱导细胞死亡的能力已在光动力疗法（PDT）中得到应用，用于治疗从牛皮癣到癌症等多种疾病。二氧化钛纳米颗粒被研究用作治疗恶性肿瘤的光敏剂以及对抗生素耐药细菌进行光动力灭活。TiO₂纳米颗粒本身及其与其他分子或生物分子的复合材料和组合都可以成功用作光动力疗法中的光敏剂。此外，各种有机化合物可以接枝到TiO₂纳米颗粒上，形成杂化材料。这些纳米结构可以显示出增加的光吸收，使其能够在医学靶向治疗中进一步应用。为了改进高效的抗癌和抗菌疗法，人们测试了许多利用二氧化钛的方法。本综述讨论了展示潜在用途范围的部分研究结果。
