Xia Linying, Zhou Chao, Liu Xiankun, Yu Yijun, Xie Qiong, Lin Hongming, Xiong Xiaochun, Zhang Songou, Liang Wenqing, Shao Haiyan
Department of Orthopedics, Zhoushan Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, 355 Xinqiao Road, Dinghai District, ZhoushanZhejiang, 316000, China.
Medical Research Center, Zhoushan Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Zhoushan, 316000, China.
Cancer Cell Int. 2025 May 25;25(1):193. doi: 10.1186/s12935-025-03827-6.
Osteosarcoma (OS), chondrosarcoma (CHS), and Ewing sarcoma (EWS) are the main types of bone cancer (BC). OS is the most common BC in this group. It is most common in children and older people, especially in their long bones. Treatments for bone sarcomas and tumors have slowly improved, so researchers began looking into additional and alternative approaches to standard therapies. Therefore, the ability to precisely manipulate metallic nanoparticles (MNPs)' form, size, charge, and surface modification makes them very useful in treating bone cancer. However, due to the biocompatibility and possible toxicity of MNPs, MNP has limits for clinical use in treating BC. Therefore, the green synthesis of MNPs is achieved by bio-reducing metallic ions, which results in the creation of NPs, using living entities or their extracts. Green MNPs derived from natural sources provide a secure and environmentally responsible solution. Benefits of green MNPs include tailored medicine delivery and biocompatibility. Green MNPs reduce damage to healthy cells while improving the targeting of bone cancer cells. In this study, we reviewed how different MNPs synthesized using green methods can help treat various types of BC. This work reviewed the usual way of making MNPs for treating BC, the problems with this standard way of making MNPs, and the benefits and possible future uses of green synthetic MNPs for treating BC.
骨肉瘤（OS）、软骨肉瘤（CHS）和尤因肉瘤（EWS）是骨癌（BC）的主要类型。骨肉瘤是这组骨癌中最常见的类型。它在儿童和老年人中最为常见，尤其是在他们的长骨中。骨肉瘤和肿瘤的治疗方法已在缓慢改进，因此研究人员开始探索标准疗法之外的其他方法。因此，精确控制金属纳米颗粒（MNP）的形状、大小、电荷和表面修饰的能力使其在骨癌治疗中非常有用。然而，由于金属纳米颗粒的生物相容性和潜在毒性，其在骨癌临床治疗中的应用存在局限性。因此，金属纳米颗粒的绿色合成是通过利用生物实体或其提取物对金属离子进行生物还原，从而生成纳米颗粒来实现的。源自天然来源的绿色金属纳米颗粒提供了一种安全且对环境负责的解决方案。绿色金属纳米颗粒的优点包括定制药物递送和生物相容性。绿色金属纳米颗粒在减少对健康细胞损伤的同时，提高了对骨癌细胞的靶向性。在本研究中，我们综述了使用绿色方法合成的不同金属纳米颗粒如何有助于治疗各种类型的骨癌。这项工作回顾了制备用于治疗骨癌的金属纳米颗粒的常用方法、这种标准制备方法存在的问题，以及绿色合成金属纳米颗粒在治疗骨癌方面的优点和可能的未来用途。
