Park Jaekwan K, Deutz Nicolaas E P, Cruthirds Clayton L, Kirschner Sarah K, Park Hangue, Madigan Michael L, Engelen Mariëlle P K J
Center for Translational Research in Aging & Longevity, Department of Health and Kinesiology, Texas A&M University, College Station, TX 77843, USA.
Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA.
J Clin Med. 2020 Feb 24;9(2):609. doi: 10.3390/jcm9020609.
Reduced balance function has been observed during balance challenging conditions in the chronic obstructive pulmonary disease (COPD) population and is associated with an increased risk of falls. This study aimed to examine postural balance during quiet standing with eyes open and functional balance in a heterogeneous group of COPD and non-COPD (control) subjects, and to identify risk factors underlying balance impairment using a large panel of methods. In COPD and control subjects, who were mostly overweight and sedentary, postural and functional balance were assessed using center-of-pressure displacement in anterior-posterior (AP) and medio-lateral (ML) directions, and the Berg Balance Scale (BBS), respectively. COPD showed 23% greater AP sway velocity ( = 0.049). The presence of oxygen therapy, fat mass, reduced neurocognitive function, and the presence of (pre)diabetes explained 71% of the variation in postural balance in COPD. Transcutaneous oxygen saturation, a history of exacerbation, and gait speed explained 83% of the variation in functional balance in COPD. Neurocognitive dysfunction was the main risk factor for postural balance impairment in the control group. This suggests that specific phenotypes of COPD patients can be identified based on their type of balance impairment.
在慢性阻塞性肺疾病（COPD）患者中，在平衡挑战条件下观察到平衡功能下降，且与跌倒风险增加相关。本研究旨在检查一组异质性的COPD患者和非COPD（对照）受试者在睁眼安静站立时的姿势平衡和功能平衡，并使用大量方法确定平衡受损的潜在风险因素。在大多超重且久坐不动的COPD患者和对照受试者中，分别使用前后（AP）和内外侧（ML）方向的压力中心位移以及伯格平衡量表（BBS）评估姿势平衡和功能平衡。COPD患者的AP摆动速度快23%（P = 0.049）。氧疗的使用、脂肪量、神经认知功能下降以及（预）糖尿病的存在解释了COPD患者姿势平衡变化的71%。经皮血氧饱和度、加重病史和步态速度解释了COPD患者功能平衡变化的83%。神经认知功能障碍是对照组姿势平衡受损的主要风险因素。这表明可以根据COPD患者的平衡受损类型识别特定的表型。
