Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Int J Mol Sci. 2020 Feb 24;21(4):1544. doi: 10.3390/ijms21041544.
Interleukin (IL)-33, a member of the IL-1 family of cytokines, is involved in innate and adaptive immune responses. IL-33 triggers pleiotropic immune functions in multiple types of immune cells, which express the IL-33 receptor, ST2. Recent studies have revealed the potential applications of IL-33 for treating acute kidney injury in preclinical animal models. However, IL-33 and IL-33-responding immune cells are reported to exhibit both detrimental and beneficial roles. The IL-33-mediated immunomodulatory functions have been investigated using loss-of-function approaches, such as IL33-deficient mice, IL-33 antagonists, or administration of exogenous IL-33 recombinant protein. This review will discuss the key findings on IL-33-mediated activation of kidney resident group 2 innate lymphoid cells (ILC2s) and summarize the current understanding of the differential functions of endogenous IL-33 and exogenous IL-33 and their potential implications in treating acute kidney injury.
白细胞介素 (IL)-33 是白细胞介素 1 家族细胞因子的成员，参与固有和适应性免疫反应。IL-33 触发多种类型免疫细胞的多效性免疫功能，这些细胞表达 IL-33 受体 ST2。最近的研究揭示了 IL-33 治疗临床前动物模型急性肾损伤的潜在应用。然而，IL-33 和 IL-33 反应性免疫细胞被报道具有有害和有益的作用。使用功能丧失方法，如 IL33 缺陷型小鼠、IL-33 拮抗剂或外源性 IL-33 重组蛋白的给药，已经研究了 IL-33 介导的免疫调节功能。本综述将讨论关于 IL-33 介导的肾脏固有 2 型先天淋巴细胞 (ILC2) 激活的关键发现，并总结内源性 IL-33 和外源性 IL-33 的不同功能及其在治疗急性肾损伤中的潜在意义。
