Department of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Int J Mol Sci. 2023 Aug 31;24(17):13504. doi: 10.3390/ijms241713504.
Intestinal diseases have always posed a serious threat to human health, with inflammatory bowel disease (IBD) being one of them. IBD is an autoimmune disease characterized by chronic inflammation, including ulcerative colitis (UC) and Crohn's disease (CD). The "alarm" cytokine IL-33, which is intimately associated with Th2 immunity, is a highly potent inflammatory factor that is considered to have dual functions-operating as both a pro-inflammatory cytokine and a transcriptional regulator. IL-33 has been shown to play a crucial role in both the onset and development of IBD. Therefore, this review focuses on the pathogenesis of IBD, the major receptor cell types, and the activities of IL-33 in innate and adaptive immunity, as well as its underlying mechanisms and conflicting conclusions in IBD. We have also summarized different medicines targeted to IL-33-associated diseases. Furthermore, we have emphasized the role of IL-33 in gastrointestinal cancer and parasitic infections, giving novel prospective therapeutic utility in the future application of IL-33.
肠道疾病一直严重威胁着人类健康，其中炎症性肠病（IBD）就是其中之一。IBD 是一种自身免疫性疾病，其特征为慢性炎症，包括溃疡性结肠炎（UC）和克罗恩病（CD）。与 Th2 免疫密切相关的“警报”细胞因子 IL-33 是一种具有双重功能的高效炎症因子，它被认为具有促炎细胞因子和转录调节因子的双重功能。IL-33 在 IBD 的发病和发展中起着至关重要的作用。因此，本综述重点介绍了 IBD 的发病机制、主要受体细胞类型，以及 IL-33 在固有和适应性免疫中的作用及其在 IBD 中的潜在机制和相互矛盾的结论。我们还总结了针对与 IL-33 相关疾病的不同药物。此外，我们强调了 IL-33 在胃肠道癌症和寄生虫感染中的作用，为未来 IL-33 的应用提供了新的治疗前景。
